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Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Neckář J, Kopkan L, Husková Z, Kolář F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Ošťádal B, Červenka L. Neckář J, et al. Among authors: kolar f. Clin Sci (Lond). 2012 Jun;122(11):513-25. doi: 10.1042/CS20110622. Clin Sci (Lond). 2012. PMID: 22324471 Free PMC article.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L. Alánová P, et al. Among authors: kolar f. Vascul Pharmacol. 2015 Oct;73:45-56. doi: 10.1016/j.vph.2015.08.013. Epub 2015 Aug 22. Vascul Pharmacol. 2015. PMID: 26304700
Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats.
Neckář J, Svatoňová A, Weissová R, Drahota Z, Zajíčková P, Brabcová I, Kolář D, Alánová P, Vašinová J, Šilhavý J, Hlaváčková M, Tauchmannová K, Milerová M, Ošťádal B, Červenka L, Žurmanová J, Kalous M, Nováková O, Novotný J, Pravenec M, Kolář F. Neckář J, et al. Among authors: kolar d, kolar f. Clin Sci (Lond). 2017 May 1;131(9):865-881. doi: 10.1042/CS20170083. Epub 2017 Mar 14. Clin Sci (Lond). 2017. PMID: 28292971
Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.
Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J. Červenka L, et al. Among authors: kolar f. J Hypertens. 2018 Jun;36(6):1326-1341. doi: 10.1097/HJH.0000000000001708. J Hypertens. 2018. PMID: 29570510 Free PMC article.
Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3.
Neckář J, Hsu A, Hye Khan MA, Gross GJ, Nithipatikom K, Cyprová M, Benák D, Hlaváčková M, Sotáková-Kašparová D, Falck JR, Sedmera D, Kolář F, Imig JD. Neckář J, et al. Among authors: kolar f. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1148-H1158. doi: 10.1152/ajpheart.00726.2017. Epub 2018 Aug 3. Am J Physiol Heart Circ Physiol. 2018. PMID: 30074840 Free PMC article.
Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats.
Hrdlička J, Neckář J, Papoušek F, Husková Z, Kikerlová S, Vaňourková Z, Vernerová Z, Akat F, Vašinová J, Hammock BD, Hwang SH, Imig JD, Falck JR, Červenka L, Kolář F. Hrdlička J, et al. Among authors: kolar f. Front Pharmacol. 2019 Mar 1;10:159. doi: 10.3389/fphar.2019.00159. eCollection 2019. Front Pharmacol. 2019. PMID: 30881303 Free PMC article.
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats.
Neckář J, Hye Khan MA, Gross GJ, Cyprová M, Hrdlička J, Kvasilová A, Falck JR, Campbell WB, Sedláková L, Škutová Š, Olejníčková V, Gregorovičová M, Sedmera D, Kolář F, Imig JD. Neckář J, et al. Among authors: kolar f. Clin Sci (Lond). 2019 Apr 29;133(8):939-951. doi: 10.1042/CS20180728. Print 2019 Apr 30. Clin Sci (Lond). 2019. PMID: 30979784 Free PMC article.
258 results