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The small molecule nitazoxanide selectively disrupts BAM-mediated folding of the outer membrane usher protein.
J Biol Chem. 2019 Sep 27;294(39):14357-14369. doi: 10.1074/jbc.RA119.009616. Epub 2019 Aug 7.
J Biol Chem. 2019.
PMID: 31391254
Free PMC article.
Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane.
Chahales P, Hoffman PS, Thanassi DG.
Chahales P, et al.
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2028-38. doi: 10.1128/AAC.02221-15. Print 2016 Apr.
Antimicrob Agents Chemother. 2016.
PMID: 26824945
Free PMC article.
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A more flexible lipoprotein sorting pathway.
Chahales P, Thanassi DG.
Chahales P, et al.
J Bacteriol. 2015 May;197(10):1702-4. doi: 10.1128/JB.00051-15. Epub 2015 Mar 9.
J Bacteriol. 2015.
PMID: 25755190
Free PMC article.
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Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria.
Chahales P, Thanassi DG.
Chahales P, et al.
Microbiol Spectr. 2015 Oct;3(5):10.1128/microbiolspec.UTI-0018-2013. doi: 10.1128/microbiolspec.UTI-0018-2013.
Microbiol Spectr. 2015.
PMID: 26542038
Free PMC article.
Review.
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A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains.
Pastagia M, Euler C, Chahales P, Fuentes-Duculan J, Krueger JG, Fischetti VA.
Pastagia M, et al. Among authors: chahales p.
Antimicrob Agents Chemother. 2011 Feb;55(2):738-44. doi: 10.1128/AAC.00890-10. Epub 2010 Nov 22.
Antimicrob Agents Chemother. 2011.
PMID: 21098252
Free PMC article.
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Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus.
Daniel A, Euler C, Collin M, Chahales P, Gorelick KJ, Fischetti VA.
Daniel A, et al. Among authors: chahales p.
Antimicrob Agents Chemother. 2010 Apr;54(4):1603-12. doi: 10.1128/AAC.01625-09. Epub 2010 Jan 19.
Antimicrob Agents Chemother. 2010.
PMID: 20086153
Free PMC article.
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PlyC: a multimeric bacteriophage lysin.
Nelson D, Schuch R, Chahales P, Zhu S, Fischetti VA.
Nelson D, et al. Among authors: chahales p.
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10765-70. doi: 10.1073/pnas.0604521103. Epub 2006 Jul 3.
Proc Natl Acad Sci U S A. 2006.
PMID: 16818874
Free PMC article.
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