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Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole TM, Toedling J, Sprüssel A, Pfeil S, Savelyeva L, Capper D, Messerschmidt C, Beule D, Groeneveld-Krentz S, Eckert C, Gambara G, Henssen AG, Finkler S, Schulte JH, Sieber A, Bluethgen N, Regenbrecht CRA, Künkele A, Lodrini M, Eggert A, Deubzer HE. Thole TM, et al. Among authors: sieber a. Int J Cancer. 2020 Feb 15;146(4):1031-1041. doi: 10.1002/ijc.32572. Epub 2019 Aug 1. Int J Cancer. 2020. PMID: 31304977
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz F, Bischoff P, Peidli S, Sieber A, Trinks A, Lüthen M, Obermayer B, Blanc E, Ruchiy Y, Sell T, Mamlouk S, Arsie R, Wei TT, Klotz-Noack K, Schwarz RF, Sawitzki B, Kamphues C, Beule D, Landthaler M, Sers C, Horst D, Blüthgen N, Morkel M. Uhlitz F, et al. Among authors: sieber a. EMBO Mol Med. 2021 Oct 7;13(10):e14123. doi: 10.15252/emmm.202114123. Epub 2021 Aug 19. EMBO Mol Med. 2021. PMID: 34409732 Free PMC article.
Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.
Dorel M, Klinger B, Mari T, Toedling J, Blanc E, Messerschmidt C, Nadler-Holly M, Ziehm M, Sieber A, Hertwig F, Beule D, Eggert A, Schulte JH, Selbach M, Blüthgen N. Dorel M, et al. Among authors: sieber a. PLoS Comput Biol. 2021 Nov 4;17(11):e1009515. doi: 10.1371/journal.pcbi.1009515. eCollection 2021 Nov. PLoS Comput Biol. 2021. PMID: 34735429 Free PMC article.
Modelling signalling networks from perturbation data.
Dorel M, Klinger B, Gross T, Sieber A, Prahallad A, Bosdriesz E, Wessels LFA, Blüthgen N. Dorel M, et al. Among authors: sieber a. Bioinformatics. 2018 Dec 1;34(23):4079-4086. doi: 10.1093/bioinformatics/bty473. Bioinformatics. 2018. PMID: 29931053
An immediate-late gene expression module decodes ERK signal duration.
Uhlitz F, Sieber A, Wyler E, Fritsche-Guenther R, Meisig J, Landthaler M, Klinger B, Blüthgen N. Uhlitz F, et al. Among authors: sieber a. Mol Syst Biol. 2017 May 3;13(5):928. doi: 10.15252/msb.20177554. Mol Syst Biol. 2017. PMID: 28468958 Free PMC article.
106 results