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Functional divergence caused by mutations in an energetic hotspot in ERK2.
Taylor CA 4th, Cormier KW, Keenan SE, Earnest S, Stippec S, Wichaidit C, Juang YC, Wang J, Shvartsman SY, Goldsmith EJ, Cobb MH. Taylor CA 4th, et al. Among authors: cobb mh. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15514-15523. doi: 10.1073/pnas.1905015116. Epub 2019 Jul 11. Proc Natl Acad Sci U S A. 2019. PMID: 31296562 Free PMC article.
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Seger R, et al. Among authors: cobb mh. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6142-6. doi: 10.1073/pnas.88.14.6142. Proc Natl Acad Sci U S A. 1991. PMID: 1712480 Free PMC article.
Protein kinases.
Goldsmith EJ, Cobb MH. Goldsmith EJ, et al. Among authors: cobb mh. Curr Opin Struct Biol. 1994 Dec;4(6):833-40. doi: 10.1016/0959-440x(94)90264-x. Curr Opin Struct Biol. 1994. PMID: 7712287 Review.
How MAP kinases are regulated.
Cobb MH, Goldsmith EJ. Cobb MH, et al. J Biol Chem. 1995 Jun 23;270(25):14843-6. doi: 10.1074/jbc.270.25.14843. J Biol Chem. 1995. PMID: 7797459 Free article. Review. No abstract available.
286 results