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Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE 3rd, Gangjee A, Matherly LH. Dekhne AS, et al. Among authors: rabinowitz jd. Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9. Mol Cancer Ther. 2019. PMID: 31289137 Free PMC article.
ZMP: a master regulator of one-carbon metabolism.
Ducker GS, Rabinowitz JD. Ducker GS, et al. Among authors: rabinowitz jd. Mol Cell. 2015 Jan 22;57(2):203-4. doi: 10.1016/j.molcel.2015.01.012. Mol Cell. 2015. PMID: 25616065 Free PMC article.
One-Carbon Metabolism in Health and Disease.
Ducker GS, Rabinowitz JD. Ducker GS, et al. Among authors: rabinowitz jd. Cell Metab. 2017 Jan 10;25(1):27-42. doi: 10.1016/j.cmet.2016.08.009. Epub 2016 Sep 15. Cell Metab. 2017. PMID: 27641100 Free PMC article. Review.
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Ducker GS, et al. Among authors: rabinowitz jd. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073064 Free PMC article.
Mitochondrial translation requires folate-dependent tRNA methylation.
Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD. Morscher RJ, et al. Among authors: rabinowitz jd. Nature. 2018 Feb 1;554(7690):128-132. doi: 10.1038/nature25460. Epub 2018 Jan 24. Nature. 2018. PMID: 29364879 Free PMC article.
5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination.
Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT; Undiagnosed Diseases Network (UDN). Rodan LH, et al. Among authors: rabinowitz jd. Mol Genet Metab. 2018 Sep;125(1-2):118-126. doi: 10.1016/j.ymgme.2018.06.006. Epub 2018 Jun 15. Mol Genet Metab. 2018. PMID: 30031689 Free PMC article.
Serine Metabolism Supports Macrophage IL-1β Production.
Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS. Rodriguez AE, et al. Among authors: rabinowitz jd. Cell Metab. 2019 Apr 2;29(4):1003-1011.e4. doi: 10.1016/j.cmet.2019.01.014. Epub 2019 Feb 14. Cell Metab. 2019. PMID: 30773464 Free PMC article.
305 results