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The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK.
Di Ceglie I, Blom AB, Davar R, Logie C, Martens JHA, Habibi E, Böttcher LM, Roth J, Vogl T, Goodyear CS, van der Kraan PM, van Lent PL, van den Bosch MH. Di Ceglie I, et al. Among authors: van der kraan pm, van lent pl, van den bosch mh. FASEB J. 2019 Sep;33(9):10104-10115. doi: 10.1096/fj.201802691RR. Epub 2019 Jun 14. FASEB J. 2019. PMID: 31199668
Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.
Schelbergen RF, Blom AB, van den Bosch MH, Slöetjes A, Abdollahi-Roodsaz S, Schreurs BW, Mort JS, Vogl T, Roth J, van den Berg WB, van Lent PL. Schelbergen RF, et al. Among authors: van lent pl, van den bosch mh, van den berg wb. Arthritis Rheum. 2012 May;64(5):1477-87. doi: 10.1002/art.33495. Arthritis Rheum. 2012. PMID: 22127564 Free article.
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.
Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: van der kraan pm, van lent pl, van den bosch mh, van den berg wb. Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480. Epub 2014 Sep 1. Ann Rheum Dis. 2016. PMID: 25180294
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.
Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van den bosch mh, van den berg wb. Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12. Ann Rheum Dis. 2015. PMID: 25969431
Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage.
van den Bosch MH, Blom AB, Sloetjes AW, Koenders MI, van de Loo FA, van den Berg WB, van Lent PL, van der Kraan PM. van den Bosch MH, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van den berg wb. Am J Pathol. 2015 Jul;185(7):1970-80. doi: 10.1016/j.ajpath.2015.03.013. Epub 2015 May 12. Am J Pathol. 2015. PMID: 25976248 Free article.
Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis.
van den Bosch MH, Gleissl TA, Blom AB, van den Berg WB, van Lent PL, van der Kraan PM. van den Bosch MH, et al. Among authors: van der kraan pm, van lent pl, van den berg wb. Rheumatology (Oxford). 2016 Sep;55(9):1536-47. doi: 10.1093/rheumatology/kev402. Epub 2015 Dec 14. Rheumatology (Oxford). 2016. PMID: 26667213 Review.
High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis.
de Munter W, van den Bosch MH, Slöetjes AW, Croce KJ, Vogl T, Roth J, Koenders MI, van de Loo FA, van den Berg WB, van der Kraan PM, van Lent PL. de Munter W, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van den bosch mh, van den berg wb. Osteoarthritis Cartilage. 2016 May;24(5):844-55. doi: 10.1016/j.joca.2015.11.016. Epub 2015 Dec 12. Osteoarthritis Cartilage. 2016. PMID: 26687826 Free article.
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.
van den Bosch MH, Blom AB, Schelbergen RF, Koenders MI, van de Loo FA, van den Berg WB, Vogl T, Roth J, van der Kraan PM, van Lent PL. van den Bosch MH, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van den berg wb. J Rheumatol. 2016 Oct;43(10):1874-1884. doi: 10.3899/jrheum.160270. Epub 2016 Aug 1. J Rheumatol. 2016. PMID: 27481901
52 results