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Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms.
Hansen J, Galatioto J, Caescu CI, Arnaud P, Calizo RC, Spronck B, Murtada SI, Borkar R, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, Humphrey JD, Jondeau G, Boileau C, Ramirez F, Iyengar R. Hansen J, et al. Among authors: humphrey jd. JCI Insight. 2019 Jun 6;4(11):e127652. doi: 10.1172/jci.insight.127652. eCollection 2019 Jun 6. JCI Insight. 2019. PMID: 31167969 Free PMC article.
Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.
Ferruzzi J, Murtada SI, Li G, Jiao Y, Uman S, Ting MY, Tellides G, Humphrey JD. Ferruzzi J, et al. Among authors: humphrey jd. Arterioscler Thromb Vasc Biol. 2016 May;36(5):919-27. doi: 10.1161/ATVBAHA.116.307436. Epub 2016 Mar 17. Arterioscler Thromb Vasc Biol. 2016. PMID: 26988590 Free PMC article.
LNK deficiency promotes acute aortic dissection and rupture.
Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS. Laroumanie F, et al. Among authors: humphrey jd. JCI Insight. 2018 Oct 18;3(20):e122558. doi: 10.1172/jci.insight.122558. JCI Insight. 2018. PMID: 30333305 Free PMC article.
Central artery stiffness and thoracic aortopathy.
Humphrey JD, Tellides G. Humphrey JD, et al. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H169-H182. doi: 10.1152/ajpheart.00205.2018. Epub 2018 Nov 9. Am J Physiol Heart Circ Physiol. 2019. PMID: 30412443 Free PMC article. Review.
Arterial Stiffness: Different Metrics, Different Meanings.
Spronck B, Humphrey JD. Spronck B, et al. Among authors: humphrey jd. J Biomech Eng. 2019 Sep 1;141(9):0910041-09100412. doi: 10.1115/1.4043486. J Biomech Eng. 2019. PMID: 30985880 Free PMC article.
401 results