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Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. Bielecki P, et al. Among authors: skadow mh. Nature. 2021 Apr;592(7852):128-132. doi: 10.1038/s41586-021-03188-w. Epub 2021 Feb 3. Nature. 2021. PMID: 33536623 Free PMC article.
The translation of non-canonical open reading frames controls mucosal immunity.
Jackson R, Kroehling L, Khitun A, Bailis W, Jarret A, York AG, Khan OM, Brewer JR, Skadow MH, Duizer C, Harman CCD, Chang L, Bielecki P, Solis AG, Steach HR, Slavoff S, Flavell RA. Jackson R, et al. Among authors: skadow mh. Nature. 2018 Dec;564(7736):434-438. doi: 10.1038/s41586-018-0794-7. Epub 2018 Dec 12. Nature. 2018. PMID: 30542152 Free PMC article.
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells.
Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. Ding C, et al. Among authors: skadow m. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203318119. doi: 10.1073/pnas.2203318119. Epub 2022 Aug 8. Proc Natl Acad Sci U S A. 2022. PMID: 35939687 Free PMC article.
IL-4 Licenses B Cell Activation Through Cholesterol Synthesis.
Steach HR, York AG, Skadow MH, Chen S, Zhao J, Williams KJ, Zhou Q, Hsieh WY, Brewer JR, Qu R, Shyer JA, Harman C, Sefik E, Mowell WK, Bailis W, Cui C, Kluger Y, Bensinger SJ, Craft J, Flavell RA. Steach HR, et al. Among authors: skadow mh. bioRxiv [Preprint]. 2024 May 15:2024.05.13.593964. doi: 10.1101/2024.05.13.593964. bioRxiv. 2024. PMID: 38798553 Free PMC article. Preprint.
IL-10 constrains sphingolipid metabolism to limit inflammation.
York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. York AG, et al. Among authors: skadow mh. Nature. 2024 Mar;627(8004):628-635. doi: 10.1038/s41586-024-07098-5. Epub 2024 Feb 21. Nature. 2024. PMID: 38383790 Free PMC article.
IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation.
York AG, Skadow MH, Qu R, Oh J, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Crawford JM, Smale ST, Bensinger SJ, Flavell RA. York AG, et al. Among authors: skadow mh. bioRxiv [Preprint]. 2023 May 8:2023.05.07.539780. doi: 10.1101/2023.05.07.539780. bioRxiv. 2023. Update in: Nature. 2024 Mar;627(8004):628-635. doi: 10.1038/s41586-024-07098-5. PMID: 37214856 Free PMC article. Updated. Preprint.