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Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis.
Burkhalter MD, Sridhar A, Sampaio P, Jacinto R, Burczyk MS, Donow C, Angenendt M; Competence Network for Congenital Heart Defects Investigators; Hempel M, Walther P, Pennekamp P, Omran H, Lopes SS, Ware SM, Philipp M. Burkhalter MD, et al. Among authors: donow c. J Clin Invest. 2019 May 16;129(7):2841-2855. doi: 10.1172/JCI98890. J Clin Invest. 2019. PMID: 31094706 Free PMC article.
Resting cells rely on the DNA helicase component MCM2 to build cilia.
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Casar Tena T, et al. Among authors: donow c. Nucleic Acids Res. 2019 Jan 10;47(1):134-151. doi: 10.1093/nar/gky945. Nucleic Acids Res. 2019. PMID: 30329080 Free PMC article.
Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish.
Burczyk MS, Burkhalter MD, Tena TC, Grisanti LA, Kauk M, Matysik S, Donow C, Kustermann M, Rothe M, Cui Y, Raad F, Laue S, Moretti A, Zimmermann WH, Wess J, Kühl M, Hoffmann C, Tilley DG, Philipp M. Burczyk MS, et al. Among authors: donow c. JCI Insight. 2019 Oct 17;4(20):e121971. doi: 10.1172/jci.insight.121971. JCI Insight. 2019. PMID: 31619590 Free PMC article.
Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage.
Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M. Burkhalter MD, et al. Among authors: donow c. Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. Cell Death Dis. 2024. PMID: 39251572 Free PMC article.
26 results