Vickers TA - Search Results

1

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Among authors: vickers ta. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929

2

Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.

Vickers TA, Crooke ST. Vickers TA, et al. PLoS One. 2014 Oct 9;9(10):e108625. doi: 10.1371/journal.pone.0108625. eCollection 2014. PLoS One. 2014. PMID: 25299183 Free PMC article.

3

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.

Vickers TA, Crooke ST. Vickers TA, et al. Nucleic Acids Res. 2015 Oct 15;43(18):8955-63. doi: 10.1093/nar/gkv920. Epub 2015 Sep 17. Nucleic Acids Res. 2015. PMID: 26384424 Free PMC article.

4

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nat Biotechnol. 2016 Aug;34(8):875-80. doi: 10.1038/nbt.3589. Epub 2016 Jul 11. Nat Biotechnol. 2016. PMID: 27398791

5

Cellular uptake and trafficking of antisense oligonucleotides.

Crooke ST, Wang S, Vickers TA, Shen W, Liang XH. Crooke ST, et al. Among authors: vickers ta. Nat Biotechnol. 2017 Mar;35(3):230-237. doi: 10.1038/nbt.3779. Epub 2017 Feb 27. Nat Biotechnol. 2017. PMID: 28244996 Review.

6

Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.

Shen W, De Hoyos CL, Sun H, Vickers TA, Liang XH, Crooke ST. Shen W, et al. Among authors: vickers ta. Nucleic Acids Res. 2018 Mar 16;46(5):2204-2217. doi: 10.1093/nar/gky060. Nucleic Acids Res. 2018. PMID: 29390093 Free PMC article.

7

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.

Wang S, Allen N, Vickers TA, Revenko AS, Sun H, Liang XH, Crooke ST. Wang S, et al. Among authors: vickers ta. Nucleic Acids Res. 2018 Apr 20;46(7):3579-3594. doi: 10.1093/nar/gky145. Nucleic Acids Res. 2018. PMID: 29514240 Free PMC article.

8

COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.

Liang XH, Sun H, Nichols JG, Allen N, Wang S, Vickers TA, Shen W, Hsu CW, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2018 Nov 2;46(19):10225-10245. doi: 10.1093/nar/gky841. Nucleic Acids Res. 2018. PMID: 30239896 Free PMC article.

9

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.

Liang XH, Nichols JG, Hsu CW, Vickers TA, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2019 Jul 26;47(13):6900-6916. doi: 10.1093/nar/gkz500. Nucleic Acids Res. 2019. PMID: 31165876 Free PMC article.

10

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.

Vickers TA, Rahdar M, Prakash TP, Crooke ST. Vickers TA, et al. Nucleic Acids Res. 2019 Nov 18;47(20):10865-10880. doi: 10.1093/nar/gkz771. Nucleic Acids Res. 2019. PMID: 31495875 Free PMC article.

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