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148 results

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Page 1
The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer.
Arai H, Elliott A, Xiu J, Wang J, Battaglin F, Kawanishi N, Soni S, Zhang W, Millstein J, Sohal D, Goldberg RM, Hall MJ, Scott AJ, Khushman M, Hwang JJ, Lou E, Weinberg BA, Marshall JL, Lockhart AC, Stafford P, Zhang J, Moretto R, Cremolini C, Korn WM, Lenz HJ. Arai H, et al. Among authors: lockhart ac. Clin Cancer Res. 2021 Jun 1;27(11):3234-3242. doi: 10.1158/1078-0432.CCR-20-3635. Epub 2021 Mar 25. Clin Cancer Res. 2021. PMID: 33766816
Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer.
Arai H, Elliott A, Millstein J, Xiu J, Ou FS, Innocenti F, Wang J, Battaglin F, Jayachandran P, Kawanishi N, Soni S, Zhang W, Sohal D, Goldberg RM, Hall MJ, Scott AJ, Khushman M, Hwang JJ, Lou E, Weinberg BA, Lockhart AC, Shields AF, Abraham JP, Magee D, Stafford P, Zhang J, Venook AP, Korn WM, Lenz HJ. Arai H, et al. Among authors: lockhart ac. Oncogene. 2022 Jan;41(2):260-267. doi: 10.1038/s41388-021-02074-z. Epub 2021 Nov 2. Oncogene. 2022. PMID: 34728807 Free PMC article.
Safety and pharmacokinetics of cabazitaxel in patients with hepatic impairment: a phase I dose-escalation study.
Sarantopoulos J, Mita AC, He A, Wade JL, Hsueh CT, Morris JC, Lockhart AC, Quinn DI, Hwang J, Mier J, Zhang W, Wack C, Yin J, Clot PF, Rixe O. Sarantopoulos J, et al. Among authors: lockhart ac. Cancer Chemother Pharmacol. 2017 Feb;79(2):339-351. doi: 10.1007/s00280-016-3210-8. Epub 2017 Jan 5. Cancer Chemother Pharmacol. 2017. PMID: 28058445 Free PMC article. Clinical Trial.
A phase I trial of temsirolimus and erlotinib in patients with refractory solid tumors.
Park H, Williams K, Trikalinos NA, Larson S, Tan B, Waqar S, Suresh R, Morgensztern D, Van Tine BA, Govindan R, Luo J, Lockhart AC, Wang-Gillam A. Park H, et al. Among authors: lockhart ac. Cancer Chemother Pharmacol. 2021 Mar;87(3):337-347. doi: 10.1007/s00280-020-04183-0. Epub 2020 Nov 6. Cancer Chemother Pharmacol. 2021. PMID: 33159216 Free PMC article. Clinical Trial.
Phase Ib study of pevonedistat, a NEDD8-activating enzyme inhibitor, in combination with docetaxel, carboplatin and paclitaxel, or gemcitabine, in patients with advanced solid tumors.
Lockhart AC, Bauer TM, Aggarwal C, Lee CB, Harvey RD, Cohen RB, Sedarati F, Nip TK, Faessel H, Dash AB, Dezube BJ, Faller DV, Dowlati A. Lockhart AC, et al. Invest New Drugs. 2019 Feb;37(1):87-97. doi: 10.1007/s10637-018-0610-0. Epub 2018 May 21. Invest New Drugs. 2019. PMID: 29781056 Free PMC article. Clinical Trial.
First-in-human study to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of the anti-CD27L antibody-drug conjugate AMG 172 in patients with relapsed/refractory renal cell carcinoma.
Massard C, Soria JC, Krauss J, Gordon M, Lockhart AC, Rasmussen E, Upreti VV, Patel S, Ngarmchamnanrith G, Henary H. Massard C, et al. Among authors: lockhart ac. Cancer Chemother Pharmacol. 2019 Jun;83(6):1057-1063. doi: 10.1007/s00280-019-03796-4. Epub 2019 Mar 26. Cancer Chemother Pharmacol. 2019. PMID: 30915497 Clinical Trial.
Phase 1 study evaluating the safety and pharmacokinetics of pralatrexate in relapsed/refractory advanced solid tumors and lymphoma patients with mild, moderate, and severe renal impairment.
Kelly KR, Gabrail N, Weitman S, Sarantopoulos J, Olszanski AJ, Edenfield W, Venitz J, Reddy G, Yang A, Hasal SJ, Lockhart AC. Kelly KR, et al. Among authors: lockhart ac. Cancer Chemother Pharmacol. 2016 Nov;78(5):929-939. doi: 10.1007/s00280-016-3142-3. Epub 2016 Sep 16. Cancer Chemother Pharmacol. 2016. PMID: 27638045 Free PMC article. Clinical Trial.
148 results