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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
Duan JJ, Lu Z, Jiang B, Stachura S, Weigelt CA, Sack JS, Khan J, Ruzanov M, Galella MA, Wu DR, Yarde M, Shen DR, Shuster DJ, Borowski V, Xie JH, Zhang L, Vanteru S, Gupta AK, Mathur A, Zhao Q, Foster W, Salter-Cid LM, Carter PH, Dhar TGM. Duan JJ, et al. Among authors: carter ph. ACS Med Chem Lett. 2019 Feb 26;10(3):367-373. doi: 10.1021/acsmedchemlett.9b00010. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891142 Free PMC article.
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Carter PH, Liu RQ, Foster WR, Tamasi JA, Tebben AJ, Favata M, Staal A, Cvijic ME, French MH, Dell V, Apanovitch D, Lei M, Zhao Q, Cunningham M, Decicco CP, Trzaskos JM, Feyen JH. Carter PH, et al. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6846-51. doi: 10.1073/pnas.0605125104. Epub 2007 Apr 11. Proc Natl Acad Sci U S A. 2007. PMID: 17428923 Free PMC article.
gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Cherney RJ, Mo R, Meyer DT, Voss ME, Yang MG, Santella JB 3rd, Duncia JV, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Mandlekar S, Cvijic ME, Barrish JC, Decicco CP, Carter PH. Cherney RJ, et al. Among authors: carter ph. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2425-30. doi: 10.1016/j.bmcl.2010.03.035. Epub 2010 Mar 10. Bioorg Med Chem Lett. 2010. PMID: 20346664
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.
Cavallaro CL, Briceno S, Chen J, Cvijic ME, Davies P, Hynes J Jr, Liu RQ, Mandlekar S, Rose AV, Tebben AJ, Van Kirk K, Watson A, Wu H, Yang G, Carter PH. Cavallaro CL, et al. Among authors: carter ph. J Med Chem. 2012 Nov 26;55(22):9643-53. doi: 10.1021/jm300896d. Epub 2012 Oct 17. J Med Chem. 2012. PMID: 23075267
112 results