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ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ. Saad MI, et al. Among authors: garbers c. EMBO Mol Med. 2019 Apr;11(4):e9976. doi: 10.15252/emmm.201809976. EMBO Mol Med. 2019. PMID: 30833304 Free PMC article.
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J. Garbers C, et al. J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990364 Free PMC article.
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J. Sommer J, et al. Among authors: garbers c. J Biol Chem. 2012 Apr 20;287(17):13743-51. doi: 10.1074/jbc.M111.349167. J Biol Chem. 2012. PMID: 22523320 Free PMC article.
Plasticity and cross-talk of interleukin 6-type cytokines.
Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J. Garbers C, et al. Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97. doi: 10.1016/j.cytogfr.2012.04.001. Epub 2012 May 15. Cytokine Growth Factor Rev. 2012. PMID: 22595692 Review.
237 results