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The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. Solon-Biet SM, et al. Among authors: le couteur dg, wu le. Cell Metab. 2014 Mar 4;19(3):418-30. doi: 10.1016/j.cmet.2014.02.009. Cell Metab. 2014. PMID: 24606899 Free PMC article.
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. North BJ, et al. Among authors: wu le. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. EMBO J. 2014. PMID: 24825348 Free PMC article.
SIRT2 controls the pentose phosphate switch.
Wu LE, Sinclair DA. Wu LE, et al. EMBO J. 2014 Jun 17;33(12):1287-8. doi: 10.15252/embj.201488713. Epub 2014 May 13. EMBO J. 2014. PMID: 24825350 Free PMC article.
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.
Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC. Mohamad M, et al. Among authors: le couteur dg, wu le. Aging Cell. 2016 Aug;15(4):706-15. doi: 10.1111/acel.12481. Epub 2016 Apr 20. Aging Cell. 2016. PMID: 27095270 Free PMC article.
Restoring stem cells - all you need is NAD(.).
Wu LE, Sinclair DA. Wu LE, et al. Cell Res. 2016 Sep;26(9):971-2. doi: 10.1038/cr.2016.80. Epub 2016 Jun 24. Cell Res. 2016. PMID: 27339086 Free PMC article.
138 results