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Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
Nayak RC, Trump LR, Aronow BJ, Myers K, Mehta P, Kalfa T, Wellendorf AM, Valencia CA, Paddison PJ, Horwitz MS, Grimes HL, Lutzko C, Cancelas JA. Nayak RC, et al. Among authors: wellendorf am. J Clin Invest. 2015 Aug 3;125(8):3103-16. doi: 10.1172/JCI80924. Epub 2015 Jul 20. J Clin Invest. 2015. PMID: 26193632 Free PMC article. Clinical Trial.
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.
Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA. Chang KH, et al. Among authors: wellendorf am. Cell Rep. 2014 Dec 24;9(6):2084-97. doi: 10.1016/j.celrep.2014.11.031. Epub 2014 Dec 18. Cell Rep. 2014. PMID: 25533346 Free PMC article.
Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation.
Chang KH, Nayak RC, Roy S, Perumbeti A, Wellendorf AM, Bezold KY, Pirman M, Hill SE, Starnes J, Loberg A, Zhou X, Inagami T, Zheng Y, Malik P, Cancelas JA. Chang KH, et al. Among authors: wellendorf am. Nat Commun. 2015 Jan 9;6:5914. doi: 10.1038/ncomms6914. Nat Commun. 2015. PMID: 25574809 Free PMC article.
Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma.
Golan K, Singh AK, Kollet O, Bertagna M, Althoff MJ, Khatib-Massalha E, Petrovich-Kopitman E, Wellendorf AM, Massalha H, Levin-Zaidman S, Dadosh T, Bohan B, V Gawali M, Dasgupta B, Lapidot T, Cancelas JA. Golan K, et al. Among authors: wellendorf am. Blood. 2020 Dec 3;136(23):2607-2619. doi: 10.1182/blood.2020005399. Blood. 2020. PMID: 32929449 Free PMC article.
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.
Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM. Serrano-Lopez J, et al. Among authors: wellendorf am. Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27. Exp Hematol. 2018. PMID: 29288703 Free PMC article.
14 results