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Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
Milite C, Feoli A, Horton JR, Rescigno D, Cipriano A, Pisapia V, Viviano M, Pepe G, Amendola G, Novellino E, Cosconati S, Cheng X, Castellano S, Sbardella G. Milite C, et al. Among authors: feoli a. J Med Chem. 2019 Mar 14;62(5):2666-2689. doi: 10.1021/acs.jmedchem.8b02008. Epub 2019 Feb 26. J Med Chem. 2019. PMID: 30753076 Free PMC article.
The emerging role of lysine methyltransferase SETD8 in human diseases.
Milite C, Feoli A, Viviano M, Rescigno D, Cianciulli A, Balzano AL, Mai A, Castellano S, Sbardella G. Milite C, et al. Among authors: feoli a. Clin Epigenetics. 2016 Sep 22;8:102. doi: 10.1186/s13148-016-0268-4. eCollection 2016. Clin Epigenetics. 2016. PMID: 27688818 Free PMC article. Review.
Combined HAT/EZH2 modulation leads to cancer-selective cell death.
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-Megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L. Petraglia F, et al. Among authors: feoli a. Oncotarget. 2018 May 22;9(39):25630-25646. doi: 10.18632/oncotarget.25428. eCollection 2018 May 22. Oncotarget. 2018. PMID: 29876013 Free PMC article.
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors.
Gandini A, Bartolini M, Tedesco D, Martinez-Gonzalez L, Roca C, Campillo NE, Zaldivar-Diez J, Perez C, Zuccheri G, Miti A, Feoli A, Castellano S, Petralla S, Monti B, Rossi M, Moda F, Legname G, Martinez A, Bolognesi ML. Gandini A, et al. Among authors: feoli a. J Med Chem. 2018 Sep 13;61(17):7640-7656. doi: 10.1021/acs.jmedchem.8b00610. Epub 2018 Aug 24. J Med Chem. 2018. PMID: 30078314
Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies.
Milite C, Amendola G, Nocentini A, Bua S, Cipriano A, Barresi E, Feoli A, Novellino E, Da Settimo F, Supuran CT, Castellano S, Cosconati S, Taliani S. Milite C, et al. Among authors: feoli a. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1697-1710. doi: 10.1080/14756366.2019.1666836. J Enzyme Inhib Med Chem. 2019. PMID: 31537132 Free PMC article.
64 results