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Page 1
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.
Polak P, Kim J, Braunstein LZ, Karlic R, Haradhavala NJ, Tiao G, Rosebrock D, Livitz D, Kübler K, Mouw KW, Kamburov A, Maruvka YE, Leshchiner I, Lander ES, Golub TR, Zick A, Orthwein A, Lawrence MS, Batra RN, Caldas C, Haber DA, Laird PW, Shen H, Ellisen LW, D'Andrea AD, Chanock SJ, Foulkes WD, Getz G. Polak P, et al. Among authors: orthwein a. Nat Genet. 2017 Oct;49(10):1476-1486. doi: 10.1038/ng.3934. Epub 2017 Aug 21. Nat Genet. 2017. PMID: 28825726 Free PMC article.
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H, Mann KK, Klein KO, Greenwood CM, Tabach Y, Park M, Côté JF, Masson JY, Maréchal A, Orthwein A. Findlay S, et al. Among authors: orthwein a. EMBO J. 2018 Sep 14;37(18):e100158. doi: 10.15252/embj.2018100158. Epub 2018 Aug 28. EMBO J. 2018. PMID: 30154076 Free PMC article.
Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families.
Matis TS, Zayed N, Labraki B, de Ladurantaye M, Matis TA, Camacho Valenzuela J, Hamel N, Atayan A, Rivera B, Tabach Y, Tonin PN, Orthwein A, Mes-Masson AM, El Haffaf Z, Foulkes WD, Polak P. Matis TS, et al. Among authors: orthwein a. NPJ Breast Cancer. 2021 Aug 25;7(1):109. doi: 10.1038/s41523-021-00315-8. NPJ Breast Cancer. 2021. PMID: 34433815 Free PMC article.
POGZ promotes homology-directed DNA repair in an HP1-dependent manner.
Heath J, Cheyou ES, Findlay S, Luo VM, Carpio EP, Lee J, Djerir B, Chen X, Morin T, Lebeau B, Karam M, Bagci H, Grapton D, Ursini-Siegel J, Côté JF, Witcher M, Richard S, Maréchal A, Orthwein A. Heath J, et al. Among authors: orthwein a. EMBO Rep. 2022 Jan 5;23(1):e51041. doi: 10.15252/embr.202051041. Epub 2021 Nov 10. EMBO Rep. 2022. PMID: 34758190 Free PMC article.
Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair.
Sherill-Rofe D, Raban O, Findlay S, Rahat D, Unterman I, Samiei A, Yasmeen A, Kaiser Z, Kuasne H, Park M, Foulkes WD, Bloch I, Zick A, Gotlieb WH, Tabach Y, Orthwein A. Sherill-Rofe D, et al. Among authors: orthwein a. NAR Cancer. 2022 Apr 8;4(2):zcac013. doi: 10.1093/narcan/zcac013. eCollection 2022 Jun. NAR Cancer. 2022. PMID: 35399185 Free PMC article.
Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability.
Simo Cheyou E, Boni J, Boulais J, Pinedo-Carpio E, Malina A, Sherill-Rofe D, Luo VM, Goncalves C, Bagci H, Maters A, Cuella-Martin R, Tabach Y, Del Rincon S, Côté JF, Rivera B, Orthwein A. Simo Cheyou E, et al. Among authors: orthwein a. PLoS Genet. 2022 Nov 14;18(11):e1010495. doi: 10.1371/journal.pgen.1010495. eCollection 2022 Nov. PLoS Genet. 2022. PMID: 36374936 Free PMC article.
The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.
Luo VM, Shen C, Worme S, Bhagrath A, Simo-Cheyou E, Findlay S, Hébert S, Wai Lam Poon W, Aryanpour Z, Zhang T, Zahedi RP, Boulais J, Buchwald ZS, Borchers CH, Côté JF, Kleinman CL, Mandl JN, Orthwein A. Luo VM, et al. Among authors: orthwein a. Mol Cell Biol. 2024 Jan;44(1):1-16. doi: 10.1080/10985549.2023.2290434. Epub 2024 Jan 29. Mol Cell Biol. 2024. PMID: 38270191
41 results