Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes.
Xiong M, Zhu Z, Tian S, Zhu R, Bai S, Fu K, Davis JG, Sun Z, Baur JA, Zheng K, Ye L.
Xiong M, et al. Among authors: zhu r, zhu z.
FASEB J. 2017 Sep;31(9):3934-3949. doi: 10.1096/fj.201700251R. Epub 2017 May 10.
FASEB J. 2017.
PMID: 28490482
Together, these results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the male germline, which may explain the infertility that has been associated with such inhibitors as rapamycin.-Xiong, M., Zhu, Z., …
Together, these results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the mal …