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Page 1
Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice.
Hancock LA, Hennessy CE, Solomon GM, Dobrinskikh E, Estrella A, Hara N, Hill DB, Kissner WJ, Markovetz MR, Grove Villalon DE, Voss ME, Tearney GJ, Carroll KS, Shi Y, Schwarz MI, Thelin WR, Rowe SM, Yang IV, Evans CM, Schwartz DA. Hancock LA, et al. Among authors: thelin wr. Nat Commun. 2018 Dec 18;9(1):5363. doi: 10.1038/s41467-018-07768-9. Nat Commun. 2018. PMID: 30560893 Free PMC article.
Disulfide disruption reverses mucus dysfunction in allergic airway disease.
Morgan LE, Jaramillo AM, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ, NeeDell JC, Hennessy CE, El-Batal HM, Magin CM, Grove Villalon DE, Duncan G, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. Morgan LE, et al. Among authors: thelin wr. Nat Commun. 2021 Jan 11;12(1):249. doi: 10.1038/s41467-020-20499-0. Nat Commun. 2021. PMID: 33431872 Free PMC article.
An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.
Ehre C, Rushton ZL, Wang B, Hothem LN, Morrison CB, Fontana NC, Markovetz MR, Delion MF, Kato T, Villalon D, Thelin WR, Esther CR Jr, Hill DB, Grubb BR, Livraghi-Butrico A, Donaldson SH, Boucher RC. Ehre C, et al. Among authors: thelin wr. Am J Respir Crit Care Med. 2019 Jan 15;199(2):171-180. doi: 10.1164/rccm.201802-0245OC. Am J Respir Crit Care Med. 2019. PMID: 30212240 Free PMC article.
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.
Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC. Esther CR Jr, et al. Among authors: thelin wr. Sci Transl Med. 2019 Apr 3;11(486):eaav3488. doi: 10.1126/scitranslmed.aav3488. Sci Transl Med. 2019. PMID: 30944166 Free PMC article.
Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease.
Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC. Hirsh AJ, et al. Among authors: thelin wr. J Pharmacol Exp Ther. 2008 Apr;325(1):77-88. doi: 10.1124/jpet.107.130443. Epub 2008 Jan 24. J Pharmacol Exp Ther. 2008. PMID: 18218832
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