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Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.
Guo Y, Zhao M, Bo T, Ma S, Yuan Z, Chen W, He Z, Hou X, Liu J, Zhang Z, Zhu Q, Wang Q, Lin X, Yang Z, Cui M, Liu L, Li Y, Yu C, Qi X, Wang Q, Zhang H, Guan Q, Zhao L, Xuan S, Yan H, Lin Y, Wang L, Li Q, Song Y, Gao L, Zhao J. Guo Y, et al. Among authors: zhang z, zhang h. Cell Res. 2019 Feb;29(2):151-166. doi: 10.1038/s41422-018-0123-6. Epub 2018 Dec 17. Cell Res. 2019. PMID: 30559440 Free PMC article.
A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2.
Li Y, Song Y, Zhao M, Guo Y, Yu C, Chen W, Shao S, Xu C, Zhou X, Zhao L, Zhang Z, Bo T, Xia Y, Proud CG, Wang X, Wang L, Zhao J, Gao L. Li Y, et al. Among authors: zhang z. Hepatology. 2017 Aug;66(2):481-497. doi: 10.1002/hep.29206. Epub 2017 Jun 27. Hepatology. 2017. PMID: 28395113 Free PMC article.
Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice.
Yao Z, Gong Y, Chen W, Shao S, Song Y, Guo H, Li Q, Liu S, Wang X, Zhang Z, Wang Q, Xu Y, Wu Y, Wan Q, Zhao X, Xuan Q, Wang D, Lin X, Xu J, Liu J, Proud CG, Wang X, Yang R, Fu L, Niu S, Kong J, Gao L, Bo T, Zhao J. Yao Z, et al. Among authors: zhang z. Nat Metab. 2023 Oct;5(10):1706-1725. doi: 10.1038/s42255-023-00896-7. Epub 2023 Sep 21. Nat Metab. 2023. PMID: 37735236 Free PMC article.
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