Greig JA - Search Results

1

AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver.

Greig JA, Calcedo R, Kuri-Cervantes L, Nordin JML, Albrecht J, Bote E, Goode T, Chroscinski EA, Bell P, Richman LK, Betts MR, Wilson JM. Greig JA, et al. Mol Ther Methods Clin Dev. 2018 Dec 5;11:191-201. doi: 10.1016/j.omtm.2018.10.012. eCollection 2018 Dec 14. Mol Ther Methods Clin Dev. 2018. PMID: 30547050 Free PMC article.

2

Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors.

Wang L, Louboutin JP, Bell P, Greig JA, Li Y, Wu D, Wilson JM. Wang L, et al. Among authors: greig ja. J Thromb Haemost. 2011 Oct;9(10):2009-19. doi: 10.1111/j.1538-7836.2011.04491.x. J Thromb Haemost. 2011. PMID: 21883883 Free PMC article.

3

Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression.

Greig JA, Peng H, Ohlstein J, Medina-Jaszek CA, Ahonkhai O, Mentzinger A, Grant RL, Roy S, Chen SJ, Bell P, Tretiakova AP, Wilson JM. Greig JA, et al. PLoS One. 2014 Nov 13;9(11):e112268. doi: 10.1371/journal.pone.0112268. eCollection 2014. PLoS One. 2014. PMID: 25393537 Free PMC article.

4

Intramuscular administration of AAV overcomes pre-existing neutralizing antibodies in rhesus macaques.

Greig JA, Calcedo R, Grant RL, Peng H, Medina-Jaszek CA, Ahonkhai O, Qin Q, Roy S, Tretiakova AP, Wilson JM. Greig JA, et al. Vaccine. 2016 Dec 7;34(50):6323-6329. doi: 10.1016/j.vaccine.2016.10.053. Epub 2016 Nov 3. Vaccine. 2016. PMID: 27817961

5

Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques.

Greig JA, Nordin JM, Bote E, Makaron L, Garnett ME, Kattenhorn LM, Bell P, Goode T, Wilson JM. Greig JA, et al. Mol Ther Methods Clin Dev. 2016 Dec 7;3:16079. doi: 10.1038/mtm.2016.79. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27933307 Free PMC article.

6

Characterization of Adeno-Associated Viral Vector-Mediated Human Factor VIII Gene Therapy in Hemophilia A Mice.

Greig JA, Wang Q, Reicherter AL, Chen SJ, Hanlon AL, Tipper CH, Clark KR, Wadsworth S, Wang L, Wilson JM. Greig JA, et al. Hum Gene Ther. 2017 May;28(5):392-402. doi: 10.1089/hum.2016.128. Epub 2017 Jan 5. Hum Gene Ther. 2017. PMID: 28056565

7

Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia.

Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM. Greig JA, et al. Hum Gene Ther Clin Dev. 2017 Mar;28(1):28-38. doi: 10.1089/humc.2017.007. Hum Gene Ther Clin Dev. 2017. PMID: 28319445 Free PMC article.

8

Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR^+/- Rhesus Macaques.

Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM. Greig JA, et al. Hum Gene Ther Clin Dev. 2017 Mar;28(1):39-50. doi: 10.1089/humc.2017.014. Hum Gene Ther Clin Dev. 2017. PMID: 28319449 Free PMC article.

9

AAV8 Gene Therapy Rescues the Newborn Phenotype of a Mouse Model of Crigler-Najjar.

Greig JA, Nordin JML, Draper C, Bell P, Wilson JM. Greig JA, et al. Hum Gene Ther. 2018 Jul;29(7):763-770. doi: 10.1089/hum.2017.185. Hum Gene Ther. 2018. PMID: 29448836

10

Optimized Adeno-Associated Viral-Mediated Human Factor VIII Gene Therapy in Cynomolgus Macaques.

Greig JA, Nordin JML, White JW, Wang Q, Bote E, Goode T, Calcedo R, Wadsworth S, Wang L, Wilson JM. Greig JA, et al. Hum Gene Ther. 2018 Jul 23. doi: 10.1089/hum.2018.080. Online ahead of print. Hum Gene Ther. 2018. PMID: 29890905

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