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Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.
Downing T, Imamura H, Decuypere S, Clark TG, Coombs GH, Cotton JA, Hilley JD, de Doncker S, Maes I, Mottram JC, Quail MA, Rijal S, Sanders M, Schönian G, Stark O, Sundar S, Vanaerschot M, Hertz-Fowler C, Dujardin JC, Berriman M. Downing T, et al. Among authors: imamura h. Genome Res. 2011 Dec;21(12):2143-56. doi: 10.1101/gr.123430.111. Epub 2011 Oct 28. Genome Res. 2011. PMID: 22038251 Free PMC article.
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Rogers MB, Hilley JD, Dickens NJ, Wilkes J, Bates PA, Depledge DP, Harris D, Her Y, Herzyk P, Imamura H, Otto TD, Sanders M, Seeger K, Dujardin JC, Berriman M, Smith DF, Hertz-Fowler C, Mottram JC. Rogers MB, et al. Among authors: imamura h. Genome Res. 2011 Dec;21(12):2129-42. doi: 10.1101/gr.122945.111. Epub 2011 Oct 28. Genome Res. 2011. PMID: 22038252 Free PMC article.
Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex.
Downing T, Stark O, Vanaerschot M, Imamura H, Sanders M, Decuypere S, de Doncker S, Maes I, Rijal S, Sundar S, Dujardin JC, Berriman M, Schönian G. Downing T, et al. Among authors: imamura h. Infect Genet Evol. 2012 Jan;12(1):149-59. doi: 10.1016/j.meegid.2011.11.005. Epub 2011 Nov 20. Infect Genet Evol. 2012. PMID: 22119748 Free PMC article.
Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.
Vanaerschot M, Decuypere S, Downing T, Imamura H, Stark O, De Doncker S, Roy S, Ostyn B, Maes L, Khanal B, Boelaert M, Schönian G, Berriman M, Chappuis F, Dujardin JC, Sundar S, Rijal S. Vanaerschot M, et al. Among authors: imamura h. J Infect Dis. 2012 Sep 1;206(5):752-5. doi: 10.1093/infdis/jis424. Epub 2012 Jun 29. J Infect Dis. 2012. PMID: 22753945 Free PMC article.
Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania.
Mannaert A, Downing T, Imamura H, Dujardin JC. Mannaert A, et al. Among authors: imamura h. Trends Parasitol. 2012 Sep;28(9):370-6. doi: 10.1016/j.pt.2012.06.003. Epub 2012 Jul 11. Trends Parasitol. 2012. PMID: 22789456 Free article. Review.
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.
Shaw CD, Lonchamp J, Downing T, Imamura H, Freeman TM, Cotton JA, Sanders M, Blackburn G, Dujardin JC, Rijal S, Khanal B, Illingworth CJ, Coombs GH, Carter KC. Shaw CD, et al. Among authors: imamura h. Mol Microbiol. 2016 Mar;99(6):1134-48. doi: 10.1111/mmi.13291. Epub 2016 Feb 9. Mol Microbiol. 2016. PMID: 26713880 Free PMC article.
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.
Imamura H, Downing T, Van den Broeck F, Sanders MJ, Rijal S, Sundar S, Mannaert A, Vanaerschot M, Berg M, De Muylder G, Dumetz F, Cuypers B, Maes I, Domagalska M, Decuypere S, Rai K, Uranw S, Bhattarai NR, Khanal B, Prajapati VK, Sharma S, Stark O, Schönian G, De Koning HP, Settimo L, Vanhollebeke B, Roy S, Ostyn B, Boelaert M, Maes L, Berriman M, Dujardin JC, Cotton JA. Imamura H, et al. Elife. 2016 Mar 22;5:e12613. doi: 10.7554/eLife.12613. Elife. 2016. PMID: 27003289 Free PMC article.
Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.
Mondelaers A, Sanchez-Cañete MP, Hendrickx S, Eberhardt E, Garcia-Hernandez R, Lachaud L, Cotton J, Sanders M, Cuypers B, Imamura H, Dujardin JC, Delputte P, Cos P, Caljon G, Gamarro F, Castanys S, Maes L. Mondelaers A, et al. Among authors: imamura h. PLoS One. 2016 Apr 28;11(4):e0154101. doi: 10.1371/journal.pone.0154101. eCollection 2016. PLoS One. 2016. PMID: 27123924 Free PMC article.
1,753 results