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Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.
Goncalves MD, Hopkins BD, Cantley LC. Goncalves MD, et al. Among authors: hopkins bd. N Engl J Med. 2018 Nov 22;379(21):2052-2062. doi: 10.1056/NEJMra1704560. N Engl J Med. 2018. PMID: 30462943 Review. No abstract available.
Obesity and Cancer Mechanisms: Cancer Metabolism.
Hopkins BD, Goncalves MD, Cantley LC. Hopkins BD, et al. J Clin Oncol. 2016 Dec 10;34(35):4277-4283. doi: 10.1200/JCO.2016.67.9712. Epub 2016 Nov 7. J Clin Oncol. 2016. PMID: 27903152 Free PMC article. Review.
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.
Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, Rao R, Mosquera JM, Robinson B, Faltas BM, Emerling BE, Gadi VK, Bernard B, Elemento O, Beltran H, Demichelis F, Kemp CJ, Grandori C, Cantley LC, Rubin MA. Pauli C, et al. Among authors: hopkins bd. Cancer Discov. 2017 May;7(5):462-477. doi: 10.1158/2159-8290.CD-16-1154. Epub 2017 Mar 22. Cancer Discov. 2017. PMID: 28331002 Free PMC article.
The PI3K Pathway in Human Disease.
Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. Fruman DA, et al. Among authors: hopkins bd. Cell. 2017 Aug 10;170(4):605-635. doi: 10.1016/j.cell.2017.07.029. Cell. 2017. PMID: 28802037 Free PMC article. Review.
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Goncalves MD, et al. Among authors: hopkins bd. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. doi: 10.1073/pnas.1714703115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311302 Free PMC article.
Cancer metabolism gets physical.
DelNero P, Hopkins BD, Cantley LC, Fischbach C. DelNero P, et al. Among authors: hopkins bd. Sci Transl Med. 2018 May 23;10(442):eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Sci Transl Med. 2018. PMID: 29794058 Free PMC article. Review.
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC. Hopkins BD, et al. Nature. 2018 Aug;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4. Nature. 2018. PMID: 30051890 Free PMC article.
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC. Wang DG, et al. Among authors: hopkins bd. Cell Rep. 2019 May 14;27(7):1991-2001.e5. doi: 10.1016/j.celrep.2019.04.070. Cell Rep. 2019. PMID: 31091439 Free PMC article.
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