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Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.
Tanaka A, Nishikawa H, Noguchi S, Sugiyama D, Morikawa H, Takeuchi Y, Ha D, Shigeta N, Kitawaki T, Maeda Y, Saito T, Shinohara Y, Kameoka Y, Iwaisako K, Monma F, Ohishi K, Karbach J, Jäger E, Sawada K, Katayama N, Takahashi N, Sakaguchi S. Tanaka A, et al. Among authors: sakaguchi s. J Exp Med. 2020 Feb 3;217(2):e20191009. doi: 10.1084/jem.20191009. J Exp Med. 2020. PMID: 31704808 Free PMC article.
Dynamics of effector and naïve Regulatory T cells throughout pregnancy.
Shigeta N, Kumasawa K, Tanaka A, Badger Wing J, Nakamura H, Sakaguchi S, Kimura T. Shigeta N, et al. Among authors: sakaguchi s. J Reprod Immunol. 2020 Aug;140:103135. doi: 10.1016/j.jri.2020.103135. Epub 2020 Apr 19. J Reprod Immunol. 2020. PMID: 32339846
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S. Kidani Y, et al. Among authors: sakaguchi s. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2114282119. doi: 10.1073/pnas.2114282119. Proc Natl Acad Sci U S A. 2022. PMID: 35140181 Free PMC article.
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, Parizot C, Taflin C, Heike T, Valeyre D, Mathian A, Nakahata T, Yamaguchi T, Nomura T, Ono M, Amoura Z, Gorochov G, Sakaguchi S. Miyara M, et al. Among authors: sakaguchi s. Immunity. 2009 Jun 19;30(6):899-911. doi: 10.1016/j.immuni.2009.03.019. Epub 2009 May 21. Immunity. 2009. PMID: 19464196 Free article.
TCR diversity and Treg cells, sometimes more is more.
Wing JB, Sakaguchi S. Wing JB, et al. Among authors: sakaguchi s. Eur J Immunol. 2011 Nov;41(11):3097-100. doi: 10.1002/eji.201142115. Epub 2011 Oct 20. Eur J Immunol. 2011. PMID: 22015985 Free article. Review.
Development and maintenance of regulatory T cells.
Ohkura N, Kitagawa Y, Sakaguchi S. Ohkura N, et al. Among authors: sakaguchi s. Immunity. 2013 Mar 21;38(3):414-23. doi: 10.1016/j.immuni.2013.03.002. Immunity. 2013. PMID: 23521883 Free article. Review.
Foxp3⁺ T(reg) cells in humoral immunity.
Wing JB, Sakaguchi S. Wing JB, et al. Among authors: sakaguchi s. Int Immunol. 2014 Feb;26(2):61-9. doi: 10.1093/intimm/dxt060. Epub 2013 Dec 9. Int Immunol. 2014. PMID: 24324208 Free PMC article. Review.
1,221 results