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Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx.
Kidney Int. 2019 Jan;95(1):94-107. doi: 10.1016/j.kint.2018.08.024. Epub 2018 Oct 31.
Kidney Int. 2019.
PMID: 30389198
Free PMC article.
A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.
Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RR.
Desideri S, et al. Among authors: onions kl.
Kidney Int. 2018 May;93(5):1086-1097. doi: 10.1016/j.kint.2017.12.003. Epub 2018 Feb 9.
Kidney Int. 2018.
PMID: 29433915
Free PMC article.
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The Authors Reply.
Desideri S, Onions KL, Butler MJ, Michel CC, Satchell SC, Salmon AHJ, Foster RR.
Desideri S, et al. Among authors: onions kl.
Kidney Int. 2018 Jul;94(1):220. doi: 10.1016/j.kint.2018.04.013.
Kidney Int. 2018.
PMID: 29933849
Free article.
No abstract available.
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VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy.
Onions KL, Gamez M, Buckner NR, Baker SL, Betteridge KB, Desideri S, Dallyn BP, Ramnath RD, Neal CR, Farmer LK, Mathieson PW, Gnudi L, Alitalo K, Bates DO, Salmon AHJ, Welsh GI, Satchell SC, Foster RR.
Onions KL, et al.
Diabetes. 2019 Jan;68(1):172-187. doi: 10.2337/db18-0045. Epub 2018 Nov 2.
Diabetes. 2019.
PMID: 30389746
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Endothelial glycocalyx restoration by growth factors in diabetic nephropathy.
Desideri S, Onions KL, Baker SL, Gamez M, El Hegni E Hussien H, Russell A, Satchell SC, Foster RR.
Desideri S, et al. Among authors: onions kl.
Biorheology. 2019;56(2-3):163-179. doi: 10.3233/BIR-180199.
Biorheology. 2019.
PMID: 31156139
Review.
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Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease.
Ramnath RD, Butler MJ, Newman G, Desideri S, Russell A, Lay AC, Neal CR, Qiu Y, Fawaz S, Onions KL, Gamez M, Crompton M, Michie C, Finch N, Coward RJ, Welsh GI, Foster RR, Satchell SC.
Ramnath RD, et al. Among authors: onions kl.
Kidney Int. 2020 May;97(5):951-965. doi: 10.1016/j.kint.2019.09.035. Epub 2019 Nov 2.
Kidney Int. 2020.
PMID: 32037077
Free PMC article.
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Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Crompton M, Ferguson JK, Ramnath RD, Onions KL, Ogier AS, Gamez M, Down CJ, Skinner L, Wong KH, Dixon LK, Sutak J, Harper SJ, Pontrelli P, Gesualdo L, Heerspink HL, Toto RD, Welsh GI, Foster RR, Satchell SC, Butler MJ.
Crompton M, et al. Among authors: onions kl.
JCI Insight. 2023 Mar 8;8(5):e154164. doi: 10.1172/jci.insight.154164.
JCI Insight. 2023.
PMID: 36749631
Free PMC article.
Clinical Trial.
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Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.
Gamez M, Elhegni HE, Fawaz S, Ho KH, Campbell NW, Copland DA, Onions KL, Butler MJ, Wasson EJ, Crompton M, Ramnath RD, Qiu Y, Yamaguchi Y, Arkill KP, Bates DO, Turnbull JE, Zubkova OV, Welsh GI, Atan D, Satchell SC, Foster RR.
Gamez M, et al. Among authors: onions kl.
Cardiovasc Diabetol. 2024 Feb 1;23(1):50. doi: 10.1186/s12933-024-02133-1.
Cardiovasc Diabetol. 2024.
PMID: 38302978
Free PMC article.
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