Gestwicki JE - Search Results

1

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Freilich R, et al. Among authors: gestwicki je. Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4. Nat Commun. 2018. PMID: 30385828 Free PMC article.

2

The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.

Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. Smith MC, et al. Among authors: gestwicki je. Biochemistry. 2013 Aug 13;52(32):5354-64. doi: 10.1021/bi4009209. Epub 2013 Aug 2. Biochemistry. 2013. PMID: 23865999 Free PMC article.

3

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. Connarn JN, et al. Among authors: gestwicki je. J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. J Biol Chem. 2014. PMID: 24327656 Free PMC article.

4

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA. Fontaine SN, et al. Among authors: gestwicki je. J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11. J Biol Chem. 2015. PMID: 25864199 Free PMC article.

5

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE. Assimon VA, et al. Among authors: gestwicki je. Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25. Biochemistry. 2015. PMID: 26565746 Free PMC article.

6

Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).

Li X, Shao H, Taylor IR, Gestwicki JE. Li X, et al. Among authors: gestwicki je. Curr Top Med Chem. 2016;16(25):2729-40. doi: 10.2174/1568026616666160413140911. Curr Top Med Chem. 2016. PMID: 27072701 Free PMC article. Review.

7

Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release.

Rauch JN, Zuiderweg ER, Gestwicki JE. Rauch JN, et al. Among authors: gestwicki je. J Biol Chem. 2016 Sep 16;291(38):19848-57. doi: 10.1074/jbc.M116.742502. Epub 2016 Jul 29. J Biol Chem. 2016. PMID: 27474739 Free PMC article.

8

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.

Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Young ZT, et al. Among authors: gestwicki je. Cell Chem Biol. 2016 Aug 18;23(8):992-1001. doi: 10.1016/j.chembiol.2016.04.014. Epub 2016 Aug 4. Cell Chem Biol. 2016. PMID: 27499529 Free PMC article.

9

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. Rauch JN, et al. Among authors: gestwicki je. J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21. J Mol Biol. 2017. PMID: 27884606 Free PMC article.

10

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.

Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE. Srinivasan SR, et al. Among authors: gestwicki je. Mol Cancer Res. 2018 Jan;16(1):58-68. doi: 10.1158/1541-7786.MCR-17-0408. Epub 2017 Sep 28. Mol Cancer Res. 2018. PMID: 28970360 Free PMC article.

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