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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Da Conceição RR, Werneck-de-Castro JP, Ignacio DL, Egri P, Németh D, Fekete C, Bernardi MM, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Gereben B, Ribeiro MO, Bianco AC. Jo S, et al. Among authors: egri p. J Clin Invest. 2019 Jan 2;129(1):230-245. doi: 10.1172/JCI123176. Epub 2018 Dec 3. J Clin Invest. 2019. PMID: 30352046 Free PMC article.
Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
McAninch EA, Jo S, Preite NZ, Farkas E, Mohácsik P, Fekete C, Egri P, Gereben B, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco AC. McAninch EA, et al. Among authors: egri p. J Clin Endocrinol Metab. 2015 Mar;100(3):920-33. doi: 10.1210/jc.2014-4092. Epub 2015 Jan 8. J Clin Endocrinol Metab. 2015. PMID: 25569702 Free PMC article.
Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism.
Jansen SW, Akintola AA, Roelfsema F, van der Spoel E, Cobbaert CM, Ballieux BE, Egri P, Kvarta-Papp Z, Gereben B, Fekete C, Slagboom PE, van der Grond J, Demeneix BA, Pijl H, Westendorp RG, van Heemst D. Jansen SW, et al. Among authors: egri p. Sci Rep. 2015 Jun 19;5:11525. doi: 10.1038/srep11525. Sci Rep. 2015. PMID: 26089239 Free PMC article.
16 results