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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors.
Yen I, Shanahan F, Merchant M, Orr C, Hunsaker T, Durk M, La H, Zhang X, Martin SE, Lin E, Chan J, Yu Y, Amin D, Neve RM, Gustafson A, Venkatanarayan A, Foster SA, Rudolph J, Klijn C, Malek S. Yen I, et al. Among authors: foster sa. Cancer Cell. 2018 Oct 8;34(4):611-625.e7. doi: 10.1016/j.ccell.2018.09.002. Cancer Cell. 2018. PMID: 30300582 Free article.
Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, Yu C, Shaw AS, Manning G, Skelton NJ, Hymowitz SG, Malek S. Foster SA, et al. Cancer Cell. 2016 Apr 11;29(4):477-493. doi: 10.1016/j.ccell.2016.02.010. Epub 2016 Mar 17. Cancer Cell. 2016. PMID: 26996308 Free article.
The RAS/MAPK Axis Gets Stressed Out.
Foster SA, Malek S. Foster SA, et al. Mol Cell. 2016 Dec 1;64(5):854-855. doi: 10.1016/j.molcel.2016.11.024. Mol Cell. 2016. PMID: 27912095 Free article.
Identifying transcriptional programs underlying cancer drug response with TraCe-seq.
Chang MT, Shanahan F, Nguyen TTT, Staben ST, Gazzard L, Yamazoe S, Wertz IE, Piskol R, Yang YA, Modrusan Z, Haley B, Evangelista M, Malek S, Foster SA, Ye X. Chang MT, et al. Among authors: foster sa. Nat Biotechnol. 2022 Jan;40(1):86-93. doi: 10.1038/s41587-021-01005-3. Epub 2021 Sep 16. Nat Biotechnol. 2022. PMID: 34531539
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation.
Rosenberg SC, Shanahan F, Yamazoe S, Kschonsak M, Zeng YJ, Lee J, Plise E, Yen I, Rose CM, Quinn JG, Gazzard LJ, Walters BT, Kirkpatrick DS, Staben ST, Foster SA, Malek S. Rosenberg SC, et al. Among authors: foster sa. Cell Chem Biol. 2023 Feb 8:S2451-9456(23)00030-2. doi: 10.1016/j.chembiol.2023.01.007. Online ahead of print. Cell Chem Biol. 2023. PMID: 36773603 Free article.
131 results