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Page 1
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE. Caenepeel S, et al. Among authors: poppe l. Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Cancer Discov. 2018. PMID: 30254093
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Tamayo NA, Bourbeau MP, Allen JR, Ashton KS, Chen JJ, Kaller MR, Nguyen TT, Nishimura N, Pettus LH, Walton M, Belmontes B, Moriguchi J, Chen K, McCarter JD, Hanestad K, Chung G, Ninniri MSS, Sun J, Poppe L, Spahr C, Hui J, Jia L, Wu T, Dahal UP, Edson KZ, Payton M. Tamayo NA, et al. Among authors: poppe l. J Med Chem. 2022 Mar 24;65(6):4972-4990. doi: 10.1021/acs.jmedchem.1c02030. Epub 2022 Mar 14. J Med Chem. 2022. PMID: 35286090
Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
Michelsen K, Jordan JB, Lewis J, Long AM, Yang E, Rew Y, Zhou J, Yakowec P, Schnier PD, Huang X, Poppe L. Michelsen K, et al. Among authors: poppe l. J Am Chem Soc. 2012 Oct 17;134(41):17059-67. doi: 10.1021/ja305839b. Epub 2012 Oct 5. J Am Chem Soc. 2012. PMID: 22991965
Solubility prediction by recursive partitioning.
Xia X, Maliski E, Cheetham J, Poppe L. Xia X, et al. Among authors: poppe l. Pharm Res. 2003 Oct;20(10):1634-40. doi: 10.1023/a:1026195503465. Pharm Res. 2003. PMID: 14620519
Hepcidin revisited, disulfide connectivity, dynamics, and structure.
Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ. Jordan JB, et al. Among authors: poppe l. J Biol Chem. 2009 Sep 4;284(36):24155-67. doi: 10.1074/jbc.M109.017764. Epub 2009 Jun 24. J Biol Chem. 2009. PMID: 19553669 Free PMC article.
Protected hinge in the immunoglobulin G2-A2 disulfide isoform.
Liu YD, Chou RY, Dillon TM, Poppe L, Spahr C, Shi SD, Flynn GC. Liu YD, et al. Among authors: poppe l. Protein Sci. 2014 Dec;23(12):1753-64. doi: 10.1002/pro.2557. Epub 2014 Oct 23. Protein Sci. 2014. PMID: 25264323 Free PMC article.
164 results