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298 results

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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, Anagnostopoulos AE, Wang A, Broadfield LA, Ford RJ, Foster RA, Bates J, Sun H, Wang T, Liu H, Ray AS, Saha AK, Greenwood J, Bhat S, Harriman G, Miao W, Rocnik JL, Westlin WF, Muti P, Tsakiridis T, Harwood HJ Jr, Kapeller R, Hoshida Y, Tanabe KK, Steinberg GR, Fuchs BC. Lally JSV, et al. Among authors: muti p. Cell Metab. 2019 Jan 8;29(1):174-182.e5. doi: 10.1016/j.cmet.2018.08.020. Epub 2018 Sep 20. Cell Metab. 2019. PMID: 30244972 Free PMC article.
AMPK β1 reduces tumor progression and improves survival in p53 null mice.
Houde VP, Donzelli S, Sacconi A, Galic S, Hammill JA, Bramson JL, Foster RA, Tsakiridis T, Kemp BE, Grasso G, Blandino G, Muti P, Steinberg GR. Houde VP, et al. Among authors: muti p. Mol Oncol. 2017 Sep;11(9):1143-1155. doi: 10.1002/1878-0261.12079. Epub 2017 Jun 28. Mol Oncol. 2017. PMID: 28544264 Free PMC article.
Salicylate enhances the response of prostate cancer to radiotherapy.
Broadfield LA, Marcinko K, Tsakiridis E, Zacharidis PG, Villani L, Lally JSV, Menjolian G, Maharaj D, Mathurin T, Smoke M, Farrell T, Muti P, Steinberg GR, Tsakiridis T. Broadfield LA, et al. Among authors: muti p. Prostate. 2019 Apr;79(5):489-497. doi: 10.1002/pros.23755. Epub 2019 Jan 4. Prostate. 2019. PMID: 30609074
Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses.
Tsakiridis EE, Broadfield L, Marcinko K, Biziotis OD, Ali A, Mekhaeil B, Ahmadi E, Singh K, Mesci A, Zacharidis PG, Anagnostopoulos AE, Berg T, Muti P, Steinberg GR, Tsakiridis T. Tsakiridis EE, et al. Among authors: muti p. Transl Oncol. 2021 Nov;14(11):101209. doi: 10.1016/j.tranon.2021.101209. Epub 2021 Aug 31. Transl Oncol. 2021. PMID: 34479029 Free PMC article.
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome.
Broadfield LA, Saigal A, Szamosi JC, Hammill JA, Bezverbnaya K, Wang D, Gautam J, Tsakiridis EE, Di Pastena F, McNicol J, Wu J, Syed S, Lally JSV, Raphenya AR, Blouin MJ, Pollak M, Sacconi A, Blandino G, McArthur AG, Schertzer JD, Surette MG, Collins SM, Bramson JL, Muti P, Tsakiridis T, Steinberg GR. Broadfield LA, et al. Among authors: muti p. Mol Metab. 2022 Jul;61:101498. doi: 10.1016/j.molmet.2022.101498. Epub 2022 Apr 20. Mol Metab. 2022. PMID: 35452877 Free PMC article.
Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.
Pulito C, Mori F, Sacconi A, Goeman F, Ferraiuolo M, Pasanisi P, Campagnoli C, Berrino F, Fanciulli M, Ford RJ, Levrero M, Pediconi N, Ciuffreda L, Milella M, Steinberg GR, Cioce M, Muti P, Strano S, Blandino G. Pulito C, et al. Among authors: muti p. Cell Discov. 2017 Jul 4;3:17022. doi: 10.1038/celldisc.2017.22. eCollection 2017. Cell Discov. 2017. PMID: 28698800 Free PMC article.
298 results