Werz O - Search Results

1

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A. Pein H, et al. Among authors: werz o. Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5. Nat Commun. 2018. PMID: 30237488 Free PMC article.

2

Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent.

Bürkert E, Rådmark O, Steinhilber D, Werz O. Bürkert E, et al. Among authors: werz o. Biochem Biophys Res Commun. 2002 Jul 26;295(4):985-91. doi: 10.1016/s0006-291x(02)00791-x. Biochem Biophys Res Commun. 2002. PMID: 12127993

3

Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.

Albert D, Zündorf I, Dingermann T, Müller WE, Steinhilber D, Werz O. Albert D, et al. Among authors: werz o. Biochem Pharmacol. 2002 Dec 15;64(12):1767-75. doi: 10.1016/s0006-2952(02)01387-4. Biochem Pharmacol. 2002. PMID: 12445866

4

5-lipoxygenase: cellular biology and molecular pharmacology.

Werz O. Werz O. Curr Drug Targets Inflamm Allergy. 2002 Mar;1(1):23-44. doi: 10.2174/1568010023344959. Curr Drug Targets Inflamm Allergy. 2002. PMID: 14561204 Review.

5

The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.

Fischer L, Hornig M, Pergola C, Meindl N, Franke L, Tanrikulu Y, Dodt G, Schneider G, Steinhilber D, Werz O. Fischer L, et al. Among authors: werz o. Br J Pharmacol. 2007 Oct;152(4):471-80. doi: 10.1038/sj.bjp.0707416. Epub 2007 Aug 20. Br J Pharmacol. 2007. PMID: 17704828 Free PMC article.

6

The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes.

Albert D, Pergola C, Koeberle A, Dodt G, Steinhilber D, Werz O. Albert D, et al. Among authors: werz o. J Leukoc Biol. 2008 Apr;83(4):1019-27. doi: 10.1189/jlb.0807531. Epub 2008 Jan 24. J Leukoc Biol. 2008. PMID: 18218859

7

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

Koeberle A, Siemoneit U, Bühring U, Northoff H, Laufer S, Albrecht W, Werz O. Koeberle A, et al. Among authors: werz o. J Pharmacol Exp Ther. 2008 Sep;326(3):975-82. doi: 10.1124/jpet.108.139444. Epub 2008 Jun 11. J Pharmacol Exp Ther. 2008. PMID: 18550688

8

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

Werz O, Greiner C, Koeberle A, Hoernig C, George S, Popescu L, Syha I, Schubert-Zsilavecz M, Steinhilber D. Werz O, et al. J Med Chem. 2008 Sep 11;51(17):5449-53. doi: 10.1021/jm800588x. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710209

9

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s. J Med Chem. 2008. PMID: 19053751

10

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo.

Rossi A, Di Paola R, Mazzon E, Genovese T, Caminiti R, Bramanti P, Pergola C, Koeberle A, Werz O, Sautebin L, Cuzzocrea S. Rossi A, et al. Among authors: werz o. J Pharmacol Exp Ther. 2009 Apr;329(1):76-86. doi: 10.1124/jpet.108.143214. Epub 2008 Dec 4. J Pharmacol Exp Ther. 2009. PMID: 19056932

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