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Biosynthesis, structure, and folding of the insulin precursor protein.
Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. Liu M, et al. Among authors: sun j. Diabetes Obes Metab. 2018 Sep;20 Suppl 2(Suppl 2):28-50. doi: 10.1111/dom.13378. Diabetes Obes Metab. 2018. PMID: 30230185 Free PMC article. Review.
"Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution.
Rege NK, Liu M, Dhayalan B, Chen YS, Smith NA, Rahimi L, Sun J, Guo H, Yang Y, Haataja L, Phillips NFB, Whittaker J, Smith BJ, Arvan P, Ismail-Beigi F, Weiss MA. Rege NK, et al. Among authors: sun j. J Biol Chem. 2020 Mar 6;295(10):3080-3098. doi: 10.1074/jbc.RA119.011389. Epub 2020 Jan 31. J Biol Chem. 2020. PMID: 32005662 Free PMC article.
Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth.
Sun J, Xiong Y, Li X, Haataja L, Chen W, Mir SA, Lv L, Madley R, Larkin D, Anjum A, Dhayalan B, Rege N, Wickramasinghe NP, Weiss MA, Itkin-Ansari P, Kaufman RJ, Ostrov DA, Arvan P, Liu M. Sun J, et al. Diabetes. 2020 May;69(5):954-964. doi: 10.2337/db19-1106. Epub 2020 Mar 5. Diabetes. 2020. PMID: 32139596 Free PMC article.
Evolution of insulin at the edge of foldability and its medical implications.
Rege NK, Liu M, Yang Y, Dhayalan B, Wickramasinghe NP, Chen YS, Rahimi L, Guo H, Haataja L, Sun J, Ismail-Beigi F, Phillips NB, Arvan P, Weiss MA. Rege NK, et al. Among authors: sun j. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29618-29628. doi: 10.1073/pnas.2010908117. Epub 2020 Nov 5. Proc Natl Acad Sci U S A. 2020. PMID: 33154160 Free PMC article.
Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, Feng W, Cui J, Sun J, Liu M. Liu S, et al. Among authors: sun j. FASEB J. 2019 Oct;33(10):11338-11348. doi: 10.1096/fj.201900442R. Epub 2019 Aug 1. FASEB J. 2019. PMID: 31311313 Free PMC article.
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of ProIR and leading to defective insulin signaling that may contribute to beta-cell failure in both MIDY and T2D.-Liu, S., Li, X., Yang, J …
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of P …
44,745 results
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