Heath PR - Search Results

1

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.

Iannitti T, Scarrott JM, Likhite S, Coldicott IRP, Lewis KE, Heath PR, Higginbottom A, Myszczynska MA, Milo M, Hautbergue GM, Meyer K, Kaspar BK, Ferraiuolo L, Shaw PJ, Azzouz M. Iannitti T, et al. Among authors: heath pr. Mol Ther Nucleic Acids. 2018 Sep 7;12:75-88. doi: 10.1016/j.omtn.2018.04.015. Epub 2018 May 3. Mol Ther Nucleic Acids. 2018. PMID: 30195799 Free PMC article.

2

Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis.

Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, Ince PG, Shaw PJ. Menzies FM, et al. Among authors: heath pr. J Neurochem. 2002 Sep;82(5):1118-28. doi: 10.1046/j.1471-4159.2002.01045.x. J Neurochem. 2002. PMID: 12358759 Free article.

3

Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis.

Heath PR, Shaw PJ. Heath PR, et al. Muscle Nerve. 2002 Oct;26(4):438-58. doi: 10.1002/mus.10186. Muscle Nerve. 2002. PMID: 12362409 Review.

4

Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.

Allen S, Heath PR, Kirby J, Wharton SB, Cookson MR, Menzies FM, Banks RE, Shaw PJ. Allen S, et al. Among authors: heath pr. J Biol Chem. 2003 Feb 21;278(8):6371-83. doi: 10.1074/jbc.M209915200. Epub 2002 Dec 9. J Biol Chem. 2003. PMID: 12475980 Free article.

5

Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

Kirby J, Halligan E, Baptista MJ, Allen S, Heath PR, Holden H, Barber SC, Loynes CA, Wood-Allum CA, Lunec J, Shaw PJ. Kirby J, et al. Among authors: heath pr. Brain. 2005 Jul;128(Pt 7):1686-706. doi: 10.1093/brain/awh503. Epub 2005 May 4. Brain. 2005. PMID: 15872021

6

Detection of mutations in whole genome-amplified DNA from laser-microdissected neurons.

Pamphlett R, Heath PR, Holden H, Ince PG, Shaw PJ. Pamphlett R, et al. Among authors: heath pr. J Neurosci Methods. 2005 Aug 30;147(1):65-7. doi: 10.1016/j.jneumeth.2005.03.005. Epub 2005 Apr 14. J Neurosci Methods. 2005. PMID: 16054517

7

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.

Wood-Allum CA, Barber SC, Kirby J, Heath P, Holden H, Mead R, Higginbottom A, Allen S, Beaujeux T, Alexson SE, Ince PG, Shaw PJ. Wood-Allum CA, et al. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15. Brain. 2006. PMID: 16702190

8

Gene expression assays.

Kirby J, Heath PR, Shaw PJ, Hamdy FC. Kirby J, et al. Among authors: heath pr. Adv Clin Chem. 2007;44:247-92. doi: 10.1016/s0065-2423(07)44008-2. Adv Clin Chem. 2007. PMID: 17682345 Review.

9

Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

Ferraiuolo L, Heath PR, Holden H, Kasher P, Kirby J, Shaw PJ. Ferraiuolo L, et al. Among authors: heath pr. J Neurosci. 2007 Aug 22;27(34):9201-19. doi: 10.1523/JNEUROSCI.1470-07.2007. J Neurosci. 2007. PMID: 17715356 Free PMC article.

10

Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS.

Ferraiuolo L, De Bono JP, Heath PR, Holden H, Kasher P, Channon KM, Kirby J, Shaw PJ. Ferraiuolo L, et al. Among authors: heath pr. J Neurochem. 2009 Jun;109(6):1714-24. doi: 10.1111/j.1471-4159.2009.06080.x. Epub 2009 Apr 1. J Neurochem. 2009. PMID: 19344372 Free article.

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