Azzouz M - Search Results

1

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.

Iannitti T, Scarrott JM, Likhite S, Coldicott IRP, Lewis KE, Heath PR, Higginbottom A, Myszczynska MA, Milo M, Hautbergue GM, Meyer K, Kaspar BK, Ferraiuolo L, Shaw PJ, Azzouz M. Iannitti T, et al. Among authors: azzouz m. Mol Ther Nucleic Acids. 2018 Sep 7;12:75-88. doi: 10.1016/j.omtn.2018.04.015. Epub 2018 May 3. Mol Ther Nucleic Acids. 2018. PMID: 30195799 Free PMC article.

2

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons.

Ning K, Drepper C, Valori CF, Ahsan M, Wyles M, Higginbottom A, Herrmann T, Shaw P, Azzouz M, Sendtner M. Ning K, et al. Among authors: azzouz m. Hum Mol Genet. 2010 Aug 15;19(16):3159-68. doi: 10.1093/hmg/ddq226. Epub 2010 Jun 4. Hum Mol Genet. 2010. PMID: 20525971

3

Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy.

Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ, Azzouz M. Valori CF, et al. Among authors: azzouz m. Sci Transl Med. 2010 Jun 9;2(35):35ra42. doi: 10.1126/scitranslmed.3000830. Sci Transl Med. 2010. PMID: 20538619

4

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.

Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo SW, Valori CF, Cox L, Sharrack B, Wharton SB, Ince PG, Shaw PJ, Azzouz M. Kirby J, et al. Among authors: azzouz m. Brain. 2011 Feb;134(Pt 2):506-17. doi: 10.1093/brain/awq345. Epub 2011 Jan 12. Brain. 2011. PMID: 21228060 Free PMC article.

5

Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).

Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M, Grierson A, Shaw PJ. Mead RJ, et al. Among authors: azzouz m. PLoS One. 2011;6(8):e23244. doi: 10.1371/journal.pone.0023244. Epub 2011 Aug 18. PLoS One. 2011. PMID: 21876739 Free PMC article.

6

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis.

Nanou A, Higginbottom A, Valori CF, Wyles M, Ning K, Shaw P, Azzouz M. Nanou A, et al. Among authors: azzouz m. Mol Ther. 2013 Aug;21(8):1486-96. doi: 10.1038/mt.2013.115. Epub 2013 Jun 4. Mol Ther. 2013. PMID: 23732987 Free PMC article.

7

PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.

Yang DJ, Wang XL, Ismail A, Ashman CJ, Valori CF, Wang G, Gao S, Higginbottom A, Ince PG, Azzouz M, Xu J, Shaw PJ, Ning K. Yang DJ, et al. Among authors: azzouz m. Cell Death Dis. 2014 Feb 27;5(2):e1096. doi: 10.1038/cddis.2014.55. Cell Death Dis. 2014. PMID: 24577094 Free PMC article.

8

Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels.

Bennett EJ, Mead RJ, Azzouz M, Shaw PJ, Grierson AJ. Bennett EJ, et al. Among authors: azzouz m. PLoS One. 2014 Sep 30;9(9):e107918. doi: 10.1371/journal.pone.0107918. eCollection 2014. PLoS One. 2014. PMID: 25268710 Free PMC article.

9

PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.

Little D, Valori CF, Mutsaers CA, Bennett EJ, Wyles M, Sharrack B, Shaw PJ, Gillingwater TH, Azzouz M, Ning K. Little D, et al. Among authors: azzouz m. Mol Ther. 2015 Feb;23(2):270-7. doi: 10.1038/mt.2014.209. Epub 2014 Nov 5. Mol Ther. 2015. PMID: 25369768 Free PMC article.

10

Current developments in gene therapy for amyotrophic lateral sclerosis.

Scarrott JM, Herranz-Martín S, Alrafiah AR, Shaw PJ, Azzouz M. Scarrott JM, et al. Among authors: azzouz m. Expert Opin Biol Ther. 2015 Jul;15(7):935-47. doi: 10.1517/14712598.2015.1044894. Epub 2015 May 10. Expert Opin Biol Ther. 2015. PMID: 25959569 Free article. Review.

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