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FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid.
Friedman ES, Li Y, Shen TD, Jiang J, Chau L, Adorini L, Babakhani F, Edwards J, Shapiro D, Zhao C, Carr RM, Bittinger K, Li H, Wu GD. Friedman ES, et al. Among authors: shapiro d. Gastroenterology. 2018 Dec;155(6):1741-1752.e5. doi: 10.1053/j.gastro.2018.08.022. Epub 2018 Aug 23. Gastroenterology. 2018. PMID: 30144429 Free PMC article. Clinical Trial.
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease.
Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, Adorini L, Sciacca CI, Clopton P, Castelloe E, Dillon P, Pruzanski M, Shapiro D. Mudaliar S, et al. Among authors: shapiro d. Gastroenterology. 2013 Sep;145(3):574-82.e1. doi: 10.1053/j.gastro.2013.05.042. Epub 2013 May 30. Gastroenterology. 2013. PMID: 23727264 Clinical Trial.
Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia.
Pataia V, McIlvride S, Papacleovoulou G, Ovadia C, McDonald JAK, Wahlström A, Jansen E, Adorini L, Shapiro D, Marchesi JR, Marschall HU, Williamson C. Pataia V, et al. Among authors: shapiro d. Am J Physiol Gastrointest Liver Physiol. 2020 Aug 1;319(2):G197-G211. doi: 10.1152/ajpgi.00126.2020. Epub 2020 Jun 29. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32597707 Free PMC article.
Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.
Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon SC, Mayo M, Kowdley KV, Vincent C, Bodhenheimer HC Jr, Parés A, Trauner M, Marschall HU, Adorini L, Sciacca C, Beecher-Jones T, Castelloe E, Böhm O, Shapiro D. Hirschfield GM, et al. Among authors: shapiro d. Gastroenterology. 2015 Apr;148(4):751-61.e8. doi: 10.1053/j.gastro.2014.12.005. Epub 2014 Dec 11. Gastroenterology. 2015. PMID: 25500425 Free article. Clinical Trial.
A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis.
Kowdley KV, Luketic V, Chapman R, Hirschfield GM, Poupon R, Schramm C, Vincent C, Rust C, Parés A, Mason A, Marschall HU, Shapiro D, Adorini L, Sciacca C, Beecher-Jones T, Böhm O, Pencek R, Jones D; Obeticholic Acid PBC Monotherapy Study Group. Kowdley KV, et al. Among authors: shapiro d. Hepatology. 2018 May;67(5):1890-1902. doi: 10.1002/hep.29569. Epub 2018 Jan 29. Hepatology. 2018. PMID: 29023915 Free PMC article. Clinical Trial.
Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes.
McIlvride S, Nikolova V, Fan HM, McDonald JAK, Wahlström A, Bellafante E, Jansen E, Adorini L, Shapiro D, Jones P, Marchesi JR, Marschall HU, Williamson C. McIlvride S, et al. Among authors: shapiro d. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E399-E410. doi: 10.1152/ajpendo.00407.2018. Epub 2019 Jun 25. Am J Physiol Endocrinol Metab. 2019. PMID: 31237448 Free PMC article.
Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis.
Loomba R, Sanyal AJ, Kowdley KV, Terrault N, Chalasani NP, Abdelmalek MF, McCullough AJ, Shringarpure R, Ferguson B, Lee L, Chen J, Liberman A, Shapiro D, Neuschwander-Tetri BA. Loomba R, et al. Among authors: shapiro d. Gastroenterology. 2019 Jan;156(1):88-95.e5. doi: 10.1053/j.gastro.2018.09.021. Epub 2018 Sep 15. Gastroenterology. 2019. PMID: 30222962 Free PMC article. Clinical Trial.
1,592 results