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20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.
Sedláková L, Kikerlová S, Husková Z, Červenková L, Chábová VČ, Zicha J, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Krátký V, Červenka L, Kopkan L. Sedláková L, et al. Among authors: imig jd. Biosci Rep. 2018 Sep 12;38(5):BSR20171496. doi: 10.1042/BSR20171496. Print 2018 Oct 31. Biosci Rep. 2018. PMID: 30054426 Free PMC article.
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats.
Certíková Chábová V, Kramer HJ, Vanecková I, Thumová M, Skaroupková P, Tesar V, Falck JR, Imig JD, Cervenka L. Certíková Chábová V, et al. Among authors: imig jd. Kidney Blood Press Res. 2007;30(5):335-46. doi: 10.1159/000107710. Epub 2007 Aug 30. Kidney Blood Press Res. 2007. PMID: 17785988
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Certíková Chábová V, et al. Among authors: imig jd. Clin Sci (Lond). 2010 Feb 23;118(10):617-32. doi: 10.1042/CS20090459. Clin Sci (Lond). 2010. PMID: 20050826 Free PMC article.
Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
Honetschlägerová Z, Husková Z, Vaňourková Z, Sporková A, Kramer HJ, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Červenka L, Kopkan L. Honetschlägerová Z, et al. Among authors: imig jd. J Physiol. 2011 Jan 1;589(Pt 1):207-19. doi: 10.1113/jphysiol.2010.199505. J Physiol. 2011. PMID: 21078594 Free PMC article.
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Honetschlägerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Chábová VC, Tesař V, Cervenka L. Honetschlägerová Z, et al. Among authors: imig jd. J Hypertens. 2011 Aug;29(8):1590-601. doi: 10.1097/HJH.0b013e328349062f. J Hypertens. 2011. PMID: 21720266 Free PMC article.
Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Kujal P, Čertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Červenka L. Kujal P, et al. Among authors: imig jd. Clin Exp Pharmacol Physiol. 2014 Mar;41(3):227-37. doi: 10.1111/1440-1681.12204. Clin Exp Pharmacol Physiol. 2014. PMID: 24471737 Free PMC article.
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. Sporková A, et al. Among authors: imig jd. Clin Exp Pharmacol Physiol. 2014 Dec;41(12):1003-13. doi: 10.1111/1440-1681.12310. Clin Exp Pharmacol Physiol. 2014. PMID: 25224811 Free PMC article.
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.
Jíchová Š, Kopkan L, Husková Z, Doleželová Š, Neckář J, Kujal P, Vernerová Z, Kramer HJ, Sadowski J, Kompanowska-Jezierska E, Reddy RN, Falck JR, Imig JD, Červenka L. Jíchová Š, et al. Among authors: imig jd. J Hypertens. 2016 Oct;34(10):2008-25. doi: 10.1097/HJH.0000000000001029. J Hypertens. 2016. PMID: 27428043 Free PMC article.
Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease.
Čertíková Chábová V, Kujal P, Škaroupková P, Varňourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesař V, Červenka L. Čertíková Chábová V, et al. Among authors: imig jd. Kidney Blood Press Res. 2018;43(2):329-349. doi: 10.1159/000487902. Epub 2018 Mar 6. Kidney Blood Press Res. 2018. PMID: 29529602 Free PMC article.
Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.
Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J. Červenka L, et al. Among authors: imig jd. J Hypertens. 2018 Jun;36(6):1326-1341. doi: 10.1097/HJH.0000000000001708. J Hypertens. 2018. PMID: 29570510 Free PMC article.
250 results