Stone E - Search Results

1

Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.

Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang XM, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, Georgiou G. Triplett TA, et al. Among authors: stone e. Nat Biotechnol. 2018 Sep;36(8):758-764. doi: 10.1038/nbt.4180. Epub 2018 Jul 16. Nat Biotechnol. 2018. PMID: 30010674 Free PMC article.

2

The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.

Cantor JR, Stone EM, Chantranupong L, Georgiou G. Cantor JR, et al. Biochemistry. 2009 Nov 24;48(46):11026-31. doi: 10.1021/bi901397h. Biochemistry. 2009. PMID: 19839645 Free PMC article.

3

Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.

Stone EM, Glazer ES, Chantranupong L, Cherukuri P, Breece RM, Tierney DL, Curley SA, Iverson BL, Georgiou G. Stone EM, et al. ACS Chem Biol. 2010 Mar 19;5(3):333-42. doi: 10.1021/cb900267j. ACS Chem Biol. 2010. PMID: 20050660 Free PMC article.

4

The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate.

Stone EM, Chantranupong L, Georgiou G. Stone EM, et al. Biochemistry. 2010 Dec 14;49(49):10582-8. doi: 10.1021/bi101542t. Epub 2010 Nov 12. Biochemistry. 2010. PMID: 21053939 Free PMC article.

5

Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.

Cantor JR, Stone EM, Georgiou G. Cantor JR, et al. Biochemistry. 2011 Apr 12;50(14):3025-33. doi: 10.1021/bi101832w. Epub 2011 Mar 18. Biochemistry. 2011. PMID: 21375249 Free PMC article.

6

Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy.

Stone E, Chantranupong L, Gonzalez C, O'Neal J, Rani M, VanDenBerg C, Georgiou G. Stone E, et al. J Control Release. 2012 Feb 28;158(1):171-9. doi: 10.1016/j.jconrel.2011.09.097. Epub 2011 Oct 6. J Control Release. 2012. PMID: 22001609 Free PMC article.

7

Engineering reduced-immunogenicity enzymes for amino acid depletion therapy in cancer.

Cantor JR, Panayiotou V, Agnello G, Georgiou G, Stone EM. Cantor JR, et al. Methods Enzymol. 2012;502:291-319. doi: 10.1016/B978-0-12-416039-2.00015-X. Methods Enzymol. 2012. PMID: 22208990 Review.

8

SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.

Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G. Romero PA, et al. Among authors: stone e. ACS Synth Biol. 2012 Jun 15;1(6):221-8. doi: 10.1021/sb300014t. ACS Synth Biol. 2012. PMID: 22737599 Free PMC article.

9

Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.

Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, Zhang Y. Li W, et al. ACS Chem Biol. 2012 Nov 16;7(11):1840-7. doi: 10.1021/cb300232n. Epub 2012 Aug 29. ACS Chem Biol. 2012. PMID: 22891768 Free PMC article.

10

De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy.

Stone E, Paley O, Hu J, Ekerdt B, Cheung NK, Georgiou G. Stone E, et al. ACS Chem Biol. 2012 Nov 16;7(11):1822-9. doi: 10.1021/cb300335j. Epub 2012 Sep 21. ACS Chem Biol. 2012. PMID: 22963240 Free PMC article.

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