Levinson NM - Search Results

1

An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.

Albanese SK, Parton DL, Işık M, Rodríguez-Laureano L, Hanson SM, Behr JM, Gradia S, Jeans C, Levinson NM, Seeliger MA, Chodera JD. Albanese SK, et al. Among authors: levinson nm. Biochemistry. 2018 Aug 7;57(31):4675-4689. doi: 10.1021/acs.biochem.7b01081. Epub 2018 Jul 26. Biochemistry. 2018. PMID: 30004690 Free PMC article.

2

A Src-like inactive conformation in the abl tyrosine kinase domain.

Levinson NM, Kuchment O, Shen K, Young MA, Koldobskiy M, Karplus M, Cole PA, Kuriyan J. Levinson NM, et al. PLoS Biol. 2006 May;4(5):e144. doi: 10.1371/journal.pbio.0040144. Epub 2006 May 2. PLoS Biol. 2006. PMID: 16640460 Free PMC article.

3

Structural basis for the recognition of c-Src by its inactivator Csk.

Levinson NM, Seeliger MA, Cole PA, Kuriyan J. Levinson NM, et al. Cell. 2008 Jul 11;134(1):124-34. doi: 10.1016/j.cell.2008.05.051. Cell. 2008. PMID: 18614016 Free PMC article.

4

The tyrosine kinase Csk dimerizes through Its SH3 domain.

Levinson NM, Visperas PR, Kuriyan J. Levinson NM, et al. PLoS One. 2009 Nov 4;4(11):e7683. doi: 10.1371/journal.pone.0007683. PLoS One. 2009. PMID: 19888460 Free PMC article.

5

A water-mediated allosteric network governs activation of Aurora kinase A.

Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM. Cyphers S, et al. Among authors: levinson nm. Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6. Nat Chem Biol. 2017. PMID: 28166210 Free PMC article.

6

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM. Ruff EF, et al. Among authors: levinson nm. Elife. 2018 Feb 21;7:e32766. doi: 10.7554/eLife.32766. Elife. 2018. PMID: 29465396 Free PMC article.

7

Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain.

Levinson NM, Boxer SG. Levinson NM, et al. PLoS One. 2012;7(4):e29828. doi: 10.1371/journal.pone.0029828. Epub 2012 Apr 6. PLoS One. 2012. PMID: 22493660 Free PMC article.

8

Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.

Rasmussen DM, Semonis MM, Greene JT, Muretta JM, Thompson AR, Toledo Ramos S, Thomas DD, Pomerantz WCK, Freedman TS, Levinson NM. Rasmussen DM, et al. Among authors: levinson nm. Elife. 2024 May 14;13:RP95481. doi: 10.7554/eLife.95481. Elife. 2024. PMID: 38742856 Free PMC article.

9

A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.

Levinson NM, Boxer SG. Levinson NM, et al. Nat Chem Biol. 2014 Feb;10(2):127-32. doi: 10.1038/nchembio.1404. Epub 2013 Dec 1. Nat Chem Biol. 2014. PMID: 24292070 Free PMC article.

10

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.

Lake EW, Muretta JM, Thompson AR, Rasmussen DM, Majumdar A, Faber EB, Ruff EF, Thomas DD, Levinson NM. Lake EW, et al. Among authors: levinson nm. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11894-E11903. doi: 10.1073/pnas.1811158115. Epub 2018 Dec 5. Proc Natl Acad Sci U S A. 2018. PMID: 30518564 Free PMC article.

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