LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Zhao Y, An L, Guo S, Huang X, Tian H, Liu L, Chen T, Sun X, Mei Q, Wang R.
Zhao Y, et al. Among authors: an l.
Epilepsia. 2021 Jan;62(1):238-249. doi: 10.1111/epi.16757. Epub 2021 Jan 8.
Epilepsia. 2021.
PMID: 33417274
METHODS: Comparative studies between LMR-101 and propofol were performed in mice to elucidate an appropriate dose range for LMR-101 that produced anticonvulsant effects without significant sedation. ...In binding assays, LMR-101 primarily inhibited tert-[(35) S] butylbicyc …
METHODS: Comparative studies between LMR-101 and propofol were performed in mice to elucidate an appropriate dose range for LMR-101 t …