Sorensen PH - Search Results

1

Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation.

Tognon CE, Rafn B, Cetinbas NM, Kamura T, Trigo G, Rotblat B, Okumura F, Matsumoto M, Chow C, Davare M, Pollak M, Mayor T, Sorensen PH. Tognon CE, et al. Among authors: sorensen ph. J Biol Chem. 2018 Aug 10;293(32):12502-12515. doi: 10.1074/jbc.RA117.000321. Epub 2018 Jun 14. J Biol Chem. 2018. PMID: 29903916 Free PMC article.

2

The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide.

Lawlor ER, Lim JF, Tao W, Poremba C, Chow CJ, Kalousek IV, Kovar H, MacDonald TJ, Sorensen PH. Lawlor ER, et al. Among authors: sorensen ph. Cancer Res. 1998 Jun 1;58(11):2469-76. Cancer Res. 1998. PMID: 9622091

3

The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation.

Tognon C, Garnett M, Kenward E, Kay R, Morrison K, Sorensen PH. Tognon C, et al. Among authors: sorensen ph. Cancer Res. 2001 Dec 15;61(24):8909-16. Cancer Res. 2001. PMID: 11751416

4

ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.

Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH. Morrison KB, et al. Among authors: sorensen ph. Oncogene. 2002 Aug 22;21(37):5684-95. doi: 10.1038/sj.onc.1205669. Oncogene. 2002. PMID: 12173038

5

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.

Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C, Sorensen PH. Tognon C, et al. Among authors: sorensen ph. Cancer Cell. 2002 Nov;2(5):367-76. doi: 10.1016/s1535-6108(02)00180-0. Cancer Cell. 2002. PMID: 12450792 Free article.

6

A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.

Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH. Lannon CL, et al. Among authors: sorensen ph. J Biol Chem. 2004 Feb 20;279(8):6225-34. doi: 10.1074/jbc.M307388200. Epub 2003 Dec 9. J Biol Chem. 2004. PMID: 14668342 Free article.

7

Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.

Tognon CE, Mackereth CD, Somasiri AM, McIntosh LP, Sorensen PH. Tognon CE, et al. Among authors: sorensen ph. Mol Cell Biol. 2004 Jun;24(11):4636-50. doi: 10.1128/MCB.24.11.4636-4650.2004. Mol Cell Biol. 2004. PMID: 15143160 Free PMC article.

8

ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages.

Lannon CL, Sorensen PH. Lannon CL, et al. Among authors: sorensen ph. Semin Cancer Biol. 2005 Jun;15(3):215-23. doi: 10.1016/j.semcancer.2005.01.003. Semin Cancer Biol. 2005. PMID: 15826836 Review.

9

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor.

Jin W, Kim BC, Tognon C, Lee HJ, Patel S, Lannon CL, Maris JM, Triche TJ, Sorensen PH, Kim SJ. Jin W, et al. Among authors: sorensen ph. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16239-44. doi: 10.1073/pnas.0503137102. Epub 2005 Oct 28. Proc Natl Acad Sci U S A. 2005. PMID: 16258068 Free PMC article.

10

The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, Podor TJ, Gleave M, Sorensen PH. Martin MJ, et al. Among authors: sorensen ph. Mol Cell Biol. 2006 Mar;26(5):1754-69. doi: 10.1128/MCB.26.5.1754-1769.2006. Mol Cell Biol. 2006. PMID: 16478996 Free PMC article.

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