Lee SK - Search Results

1

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling.

Shin W, Lee SK, Hwang JH, Park JC, Cho YH, Ro EJ, Song Y, Seo HR, Choi KY. Shin W, et al. Among authors: lee sk. Exp Mol Med. 2018 Jun 6;50(6):1-10. doi: 10.1038/s12276-018-0102-5. Exp Mol Med. 2018. PMID: 29884842 Free PMC article.

2

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.

Cha PH, Cho YH, Lee SK, Lee J, Jeong WJ, Moon BS, Yun JH, Yang JS, Choi S, Yoon J, Kim HY, Kim MY, Kaduwal S, Lee W, Min do S, Kim H, Han G, Choi KY. Cha PH, et al. Among authors: lee w, lee sk, lee j. Nat Chem Biol. 2016 Aug;12(8):593-600. doi: 10.1038/nchembio.2103. Epub 2016 Jun 13. Nat Chem Biol. 2016. PMID: 27294323

3

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.

Cho YH, Cha PH, Kaduwal S, Park JC, Lee SK, Yoon JS, Shin W, Kim H, Ro EJ, Koo KH, Park KS, Han G, Choi KY. Cho YH, et al. Among authors: lee sk. Oncotarget. 2016 Dec 6;7(49):81727-81740. doi: 10.18632/oncotarget.13172. Oncotarget. 2016. PMID: 27835580 Free PMC article.

4

Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis.

Lee SK, Hwang JH, Choi KY. Lee SK, et al. Adv Biol Regul. 2018 May;68:46-54. doi: 10.1016/j.jbior.2018.01.001. Epub 2018 Jan 10. Adv Biol Regul. 2018. PMID: 29449169 Review.

5

β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β.

Lee SK, Jeong WJ, Cho YH, Cha PH, Yoon JS, Ro EJ, Choi S, Oh JM, Heo Y, Kim H, Min DS, Han G, Lee W, Choi KY. Lee SK, et al. Among authors: lee w. EMBO Rep. 2018 Dec;19(12):e46060. doi: 10.15252/embr.201846060. Epub 2018 Nov 9. EMBO Rep. 2018. PMID: 30413483 Free PMC article.

6

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab.

Lee SK, Cho YH, Cha PH, Yoon JS, Ro EJ, Jeong WJ, Park J, Kim H, Il Kim T, Min DS, Han G, Choi KY. Lee SK, et al. Exp Mol Med. 2018 Nov 20;50(11):1-12. doi: 10.1038/s12276-018-0182-2. Exp Mol Med. 2018. PMID: 30459318 Free PMC article.

7

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.

Jeong WJ, Park JC, Kim WS, Ro EJ, Jeon SH, Lee SK, Park YN, Min DS, Choi KY. Jeong WJ, et al. Among authors: lee sk. Nat Commun. 2019 Jan 17;10(1):295. doi: 10.1038/s41467-018-08230-6. Nat Commun. 2019. PMID: 30655611 Free PMC article.

8

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer.

Park J, Cho YH, Shin WJ, Lee SK, Lee J, Kim T, Cha PH, Yang JS, Cho J, Min DS, Han G, Lee HY, Choi KY. Park J, et al. Among authors: lee sk, lee j, lee hy. Sci Rep. 2019 Jan 24;9(1):648. doi: 10.1038/s41598-018-37059-8. Sci Rep. 2019. PMID: 30679620 Free PMC article.

9

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells.

Lee KH, Jeong WJ, Cha PH, Lee SK, Min DS, Choi KY. Lee KH, et al. Among authors: lee sk. Oncotarget. 2017 Dec 14;8(70):115596-115608. doi: 10.18632/oncotarget.23313. eCollection 2017 Dec 29. Oncotarget. 2017. PMID: 29383184 Free PMC article.

10

A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS.

Ryu WJ, Lee JE, Cho YH, Lee G, Seo MK, Lee SK, Hwang JH, Min DS, Noh SH, Paik S, Kim S, Cheong JH, Choi KY. Ryu WJ, et al. Among authors: lee g, lee sk, lee je. Cancers (Basel). 2019 Apr 8;11(4):496. doi: 10.3390/cancers11040496. Cancers (Basel). 2019. PMID: 30965636 Free PMC article.

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