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3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Rey-Carrizo M, et al. Among authors: ma c. J Med Chem. 2013 Nov 27;56(22):9265-74. doi: 10.1021/jm401340p. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24237039 Free PMC article.
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.
Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Rey-Carrizo M, et al. Among authors: ma c. J Med Chem. 2014 Jul 10;57(13):5738-47. doi: 10.1021/jm5005804. Epub 2014 Jun 30. J Med Chem. 2014. PMID: 24941437 Free PMC article.
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