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Page 1
Addressing the dNTP bottleneck restricting prime editing activity.
Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Joynt AT, Kelly K, Guo D, Chen Z, Lee JM, Schiffer CA, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Ponnienselvan K, et al. Among authors: sontheimer ej. bioRxiv [Preprint]. 2023 Oct 29:2023.10.21.563443. doi: 10.1101/2023.10.21.563443. bioRxiv. 2023. PMID: 37904991 Free PMC article. Preprint.
Viruses use RNA decoys to thwart CRISPR defences.
Kraus C, Sontheimer EJ. Kraus C, et al. Among authors: sontheimer ej. Nature. 2023 Nov;623(7987):490-491. doi: 10.1038/d41586-023-03133-z. Nature. 2023. PMID: 37853195 No abstract available.
Invasive DNA, chopped and in the CRISPR.
Marraffini LA, Sontheimer EJ. Marraffini LA, et al. Among authors: sontheimer ej. Structure. 2009 Jun 10;17(6):786-8. doi: 10.1016/j.str.2009.05.002. Structure. 2009. PMID: 19523896 Free PMC article.
Naturally Occurring Off-Switches for CRISPR-Cas9.
Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR. Pawluk A, et al. Among authors: sontheimer ej. Cell. 2016 Dec 15;167(7):1829-1838.e9. doi: 10.1016/j.cell.2016.11.017. Epub 2016 Dec 8. Cell. 2016. PMID: 27984730 Free PMC article.
A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. Harrington LB, et al. Among authors: sontheimer ej. Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24. Cell. 2017. PMID: 28844692 Free PMC article.
Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.
Mir A, Edraki A, Lee J, Sontheimer EJ. Mir A, et al. Among authors: sontheimer ej. ACS Chem Biol. 2018 Feb 16;13(2):357-365. doi: 10.1021/acschembio.7b00855. Epub 2017 Dec 20. ACS Chem Biol. 2018. PMID: 29202216 Free PMC article. Review.
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.
Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, Maxwell KL. Thavalingam A, et al. Among authors: sontheimer ej. Nat Commun. 2019 Jun 26;10(1):2806. doi: 10.1038/s41467-019-10577-3. Nat Commun. 2019. PMID: 31243272 Free PMC article.
117 results