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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Sanchez CG, Acker CM, Gray A, Varadarajan M, Song C, Cochran NR, Paula S, Lindeman A, An S, McAllister G, Alford J, Reece-Hoyes J, Russ C, Craig L, Capre K, Doherty C, Hoffman GR, Luchansky SJ, Polydoro M, Dolmetsch R, Elwood F. Sanchez CG, et al. Among authors: polydoro m. Commun Biol. 2021 Jun 14;4(1):736. doi: 10.1038/s42003-021-02272-1. Commun Biol. 2021. PMID: 34127790 Free PMC article.
Targeting tau: Clinical trials and novel therapeutic approaches.
VandeVrede L, Boxer AL, Polydoro M. VandeVrede L, et al. Among authors: polydoro m. Neurosci Lett. 2020 Jul 13;731:134919. doi: 10.1016/j.neulet.2020.134919. Epub 2020 May 4. Neurosci Lett. 2020. PMID: 32380145 Free PMC article. Review.
Tau: From research to clinical development.
Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M. Holtzman DM, et al. Among authors: polydoro m. Alzheimers Dement. 2016 Oct;12(10):1033-1039. doi: 10.1016/j.jalz.2016.03.018. Epub 2016 May 4. Alzheimers Dement. 2016. PMID: 27154059 Review.
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease.
Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Pooler AM, et al. Among authors: polydoro m. Acta Neuropathol Commun. 2015 Mar 24;3:14. doi: 10.1186/s40478-015-0199-x. Acta Neuropathol Commun. 2015. PMID: 25853174 Free PMC article.
32 results