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A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.
Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R, Aizaki H, Muramatsu M, Sureau C, Wakita T, Matano T, Watashi K. Saso W, et al. Among authors: ohki m. Biochem Biophys Res Commun. 2018 Jun 22;501(2):374-379. doi: 10.1016/j.bbrc.2018.04.187. Epub 2018 May 11. Biochem Biophys Res Commun. 2018. PMID: 29730285
Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization.
Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH, Park SY, Ohtani N, Muramatsu M, Iwami S, Tanaka Y, Sureau C, Wakita T, Watashi K. Iwamoto M, et al. Among authors: ohki m. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5. Proc Natl Acad Sci U S A. 2019. PMID: 30952782 Free PMC article.
The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network.
Iwamoto M, Saso W, Nishioka K, Ohashi H, Sugiyama R, Ryo A, Ohki M, Yun JH, Park SY, Ohshima T, Suzuki R, Aizaki H, Muramatsu M, Matano T, Iwami S, Sureau C, Wakita T, Watashi K. Iwamoto M, et al. Among authors: ohki m. J Biol Chem. 2020 Jan 17;295(3):800-807. doi: 10.1074/jbc.AC119.010366. Epub 2019 Dec 12. J Biol Chem. 2020. PMID: 31836663 Free PMC article.
Direct observation of ligand migration within human hemoglobin at work.
Shibayama N, Sato-Tomita A, Ohki M, Ichiyanagi K, Park SY. Shibayama N, et al. Among authors: ohki m. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4741-4748. doi: 10.1073/pnas.1913663117. Epub 2020 Feb 18. Proc Natl Acad Sci U S A. 2020. PMID: 32071219 Free PMC article.
Structural insights into the HBV receptor and bile acid transporter NTCP.
Park JH, Iwamoto M, Yun JH, Uchikubo-Kamo T, Son D, Jin Z, Yoshida H, Ohki M, Ishimoto N, Mizutani K, Oshima M, Muramatsu M, Wakita T, Shirouzu M, Liu K, Uemura T, Nomura N, Iwata S, Watashi K, Tame JRH, Nishizawa T, Lee W, Park SY. Park JH, et al. Among authors: ohki m. Nature. 2022 Jun;606(7916):1027-1031. doi: 10.1038/s41586-022-04857-0. Epub 2022 May 17. Nature. 2022. PMID: 35580630 Free PMC article.
393 results