Frydman J - Search Results

1

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

Geller R, Pechmann S, Acevedo A, Andino R, Frydman J. Geller R, et al. Among authors: frydman j. Nat Commun. 2018 May 3;9(1):1781. doi: 10.1038/s41467-018-04203-x. Nat Commun. 2018. PMID: 29725062 Free PMC article.

2

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

Tam S, Geller R, Spiess C, Frydman J. Tam S, et al. Among authors: frydman j. Nat Cell Biol. 2006 Oct;8(10):1155-62. doi: 10.1038/ncb1477. Epub 2006 Sep 17. Nat Cell Biol. 2006. PMID: 16980959 Free PMC article.

3

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.

Geller R, Vignuzzi M, Andino R, Frydman J. Geller R, et al. Among authors: frydman j. Genes Dev. 2007 Jan 15;21(2):195-205. doi: 10.1101/gad.1505307. Genes Dev. 2007. PMID: 17234885 Free PMC article.

4

Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.

del Alamo M, Hogan DJ, Pechmann S, Albanese V, Brown PO, Frydman J. del Alamo M, et al. Among authors: frydman j. PLoS Biol. 2011 Jul;9(7):e1001100. doi: 10.1371/journal.pbio.1001100. Epub 2011 Jul 12. PLoS Biol. 2011. PMID: 21765803 Free PMC article.

5

Broad action of Hsp90 as a host chaperone required for viral replication.

Geller R, Taguwa S, Frydman J. Geller R, et al. Among authors: frydman j. Biochim Biophys Acta. 2012 Mar;1823(3):698-706. doi: 10.1016/j.bbamcr.2011.11.007. Epub 2011 Dec 2. Biochim Biophys Acta. 2012. PMID: 22154817 Free PMC article. Review.

6

The molecular architecture of the eukaryotic chaperonin TRiC/CCT.

Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J. Leitner A, et al. Among authors: frydman j. Structure. 2012 May 9;20(5):814-25. doi: 10.1016/j.str.2012.03.007. Epub 2012 Apr 12. Structure. 2012. PMID: 22503819 Free PMC article.

7

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding.

Pechmann S, Frydman J. Pechmann S, et al. Among authors: frydman j. Nat Struct Mol Biol. 2013 Feb;20(2):237-43. doi: 10.1038/nsmb.2466. Epub 2012 Dec 23. Nat Struct Mol Biol. 2013. PMID: 23262490 Free PMC article.

8

The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis.

Willmund F, del Alamo M, Pechmann S, Chen T, Albanèse V, Dammer EB, Peng J, Frydman J. Willmund F, et al. Among authors: frydman j. Cell. 2013 Jan 17;152(1-2):196-209. doi: 10.1016/j.cell.2012.12.001. Cell. 2013. PMID: 23332755 Free PMC article.

9

The ribosome as a hub for protein quality control.

Pechmann S, Willmund F, Frydman J. Pechmann S, et al. Among authors: frydman j. Mol Cell. 2013 Feb 7;49(3):411-21. doi: 10.1016/j.molcel.2013.01.020. Mol Cell. 2013. PMID: 23395271 Free PMC article. Review.

10

Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus.

Geller R, Andino R, Frydman J. Geller R, et al. Among authors: frydman j. PLoS One. 2013;8(2):e56762. doi: 10.1371/journal.pone.0056762. Epub 2013 Feb 27. PLoS One. 2013. PMID: 23460813 Free PMC article.

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