Scammells PJ - Search Results

1

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D₂ Receptor.

Fyfe TJ, Zarzycka B, Lim HD, Kellam B, Mistry SN, Katrich V, Scammells PJ, Lane JR, Capuano B. Fyfe TJ, et al. Among authors: scammells pj. J Med Chem. 2019 Jan 10;62(1):174-206. doi: 10.1021/acs.jmedchem.7b01565. Epub 2018 May 15. J Med Chem. 2019. PMID: 29683325

2

2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers.

Nikolakopoulos G, Figler H, Linden J, Scammells PJ. Nikolakopoulos G, et al. Among authors: scammells pj. Bioorg Med Chem. 2006 Apr 1;14(7):2358-65. doi: 10.1016/j.bmc.2005.11.018. Epub 2005 Nov 28. Bioorg Med Chem. 2006. PMID: 16314104

3

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. Aurelio L, et al. Among authors: scammells pj. Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. doi: 10.1016/j.bmc.2007.10.065. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17980606

4

2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.

Ferguson GN, Valant C, Horne J, Figler H, Flynn BL, Linden J, Chalmers DK, Sexton PM, Christopoulos A, Scammells PJ. Ferguson GN, et al. Among authors: scammells pj. J Med Chem. 2008 Oct 9;51(19):6165-72. doi: 10.1021/jm800557d. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771255 Free PMC article.

5

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: scammells pj. J Med Chem. 2009 Jul 23;52(14):4543-7. doi: 10.1021/jm9002582. J Med Chem. 2009. PMID: 19514747

6

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Aurelio L, Valant C, Figler H, Flynn BL, Linden J, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: scammells pj. Bioorg Med Chem. 2009 Oct 15;17(20):7353-61. doi: 10.1016/j.bmc.2009.08.024. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19751980 Free PMC article.

7

Design strategies for bivalent ligands targeting GPCRs.

Shonberg J, Scammells PJ, Capuano B. Shonberg J, et al. Among authors: scammells pj. ChemMedChem. 2011 Jun 6;6(6):963-74. doi: 10.1002/cmdc.201100101. Epub 2011 Apr 21. ChemMedChem. 2011. PMID: 21520422 Review.

8

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

Aurelio L, Christopoulos A, Flynn BL, Scammells PJ, Sexton PM, Valant C. Aurelio L, et al. Among authors: scammells pj. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3704-7. doi: 10.1016/j.bmcl.2011.04.080. Epub 2011 May 4. Bioorg Med Chem Lett. 2011. PMID: 21612922

9

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. Among authors: scammells pj. J Biol Chem. 2012 Jan 2;287(1):650-659. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

10

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Valant C, Aurelio L, Devine SM, Ashton TD, White JM, Sexton PM, Christopoulos A, Scammells PJ. Valant C, et al. Among authors: scammells pj. J Med Chem. 2012 Mar 8;55(5):2367-75. doi: 10.1021/jm201600e. Epub 2012 Feb 17. J Med Chem. 2012. PMID: 22315963

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

160 results

Search Page

Filters