Mistry SN - Search Results

1

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D₂ Receptor.

Fyfe TJ, Zarzycka B, Lim HD, Kellam B, Mistry SN, Katrich V, Scammells PJ, Lane JR, Capuano B. Fyfe TJ, et al. Among authors: mistry sn. J Med Chem. 2019 Jan 10;62(1):174-206. doi: 10.1021/acs.jmedchem.7b01565. Epub 2018 May 15. J Med Chem. 2019. PMID: 29683325

2

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B. Baker JG, et al. Among authors: mistry sn. J Med Chem. 2011 Oct 13;54(19):6874-87. doi: 10.1021/jm2008562. Epub 2011 Sep 16. J Med Chem. 2011. PMID: 21870877 Free PMC article.

3

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B. Mistry SN, et al. J Med Chem. 2013 May 23;56(10):3852-65. doi: 10.1021/jm400348g. Epub 2013 May 10. J Med Chem. 2013. PMID: 23614528 Free PMC article.

4

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

Mistry SN, Valant C, Sexton PM, Capuano B, Christopoulos A, Scammells PJ. Mistry SN, et al. J Med Chem. 2013 Jun 27;56(12):5151-72. doi: 10.1021/jm400540b. Epub 2013 Jun 17. J Med Chem. 2013. PMID: 23718562

5

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

Abdul-Ridha A, López L, Keov P, Thal DM, Mistry SN, Sexton PM, Lane JR, Canals M, Christopoulos A. Abdul-Ridha A, et al. Among authors: mistry sn. J Biol Chem. 2014 Feb 28;289(9):6067-79. doi: 10.1074/jbc.M113.539080. Epub 2014 Jan 17. J Biol Chem. 2014. PMID: 24443568 Free PMC article.

6

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.

Cook AE, Mistry SN, Gregory KJ, Furness SG, Sexton PM, Scammells PJ, Conigrave AD, Christopoulos A, Leach K. Cook AE, et al. Among authors: mistry sn. Br J Pharmacol. 2015 Jan;172(1):185-200. doi: 10.1111/bph.12937. Epub 2014 Dec 1. Br J Pharmacol. 2015. PMID: 25220431 Free PMC article.

7

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ, McGowan S. Mistry SN, et al. J Med Chem. 2014 Nov 13;57(21):9168-83. doi: 10.1021/jm501323a. Epub 2014 Oct 24. J Med Chem. 2014. PMID: 25299353

8

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

Abdul-Ridha A, Lane JR, Mistry SN, López L, Sexton PM, Scammells PJ, Christopoulos A, Canals M. Abdul-Ridha A, et al. Among authors: mistry sn. J Biol Chem. 2014 Nov 28;289(48):33701-11. doi: 10.1074/jbc.M114.604967. Epub 2014 Oct 17. J Biol Chem. 2014. PMID: 25326383 Free PMC article.

9

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Paiardini A, Bamert RS, Kannan-Sivaraman K, Drinkwater N, Mistry SN, Scammells PJ, McGowan S. Paiardini A, et al. Among authors: mistry sn. PLoS One. 2015 Feb 20;10(2):e0115859. doi: 10.1371/journal.pone.0115859. eCollection 2015. PLoS One. 2015. PMID: 25700165 Free PMC article.

10

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.

Shonberg J, Draper-Joyce C, Mistry SN, Christopoulos A, Scammells PJ, Lane JR, Capuano B. Shonberg J, et al. Among authors: mistry sn. J Med Chem. 2015 Jul 9;58(13):5287-307. doi: 10.1021/acs.jmedchem.5b00581. Epub 2015 Jun 24. J Med Chem. 2015. PMID: 26052807 Free article.

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