Zhang H - Search Results

1

Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Xin M, et al. Among authors: zhang sq, zhang h. J Enzyme Inhib Med Chem. 2018 Dec;33(1):651-656. doi: 10.1080/14756366.2018.1444608. J Enzyme Inhib Med Chem. 2018. PMID: 29536777 Free PMC article.

2

Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety.

Zhang H, Xin MH, Xie XX, Mao S, Zuo SJ, Lu SM, Zhang SQ. Zhang H, et al. Among authors: zhang sq. Bioorg Med Chem. 2015 Dec 15;23(24):7765-76. doi: 10.1016/j.bmc.2015.11.027. Epub 2015 Nov 22. Bioorg Med Chem. 2015. PMID: 26652969

3

Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors.

Hei YY, Xin M, Zhang H, Xie XX, Mao S, Zhang SQ. Hei YY, et al. Among authors: zhang sq, zhang h. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4408-4413. doi: 10.1016/j.bmcl.2016.08.015. Epub 2016 Aug 8. Bioorg Med Chem Lett. 2016. PMID: 27544401

4

Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors.

Xin M, Hei YY, Zhang H, Shen Y, Zhang SQ. Xin M, et al. Among authors: zhang sq, zhang h. Bioorg Med Chem Lett. 2017 May 1;27(9):1972-1977. doi: 10.1016/j.bmcl.2017.03.020. Epub 2017 Mar 11. Bioorg Med Chem Lett. 2017. PMID: 28325601

5

Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.

Zhang H, Wang J, Shen Y, Wang HY, Duan WM, Zhao HY, Hei YY, Xin M, Cao YX, Zhang SQ. Zhang H, et al. Among authors: zhang sq. Eur J Med Chem. 2018 Mar 25;148:221-237. doi: 10.1016/j.ejmech.2018.02.051. Epub 2018 Feb 16. Eur J Med Chem. 2018. PMID: 29466773

6

Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Xin M, et al. Among authors: zhang sq, zhang h. Bioorg Med Chem. 2018 May 1;26(8):2028-2040. doi: 10.1016/j.bmc.2018.03.002. Epub 2018 Mar 2. Bioorg Med Chem. 2018. PMID: 29534936

7

Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp² C-H bond amination mediated by cupric acetate.

Zhao HY, Wang HY, Mao S, Xin M, Zhang H, Zhang SQ. Zhao HY, et al. Among authors: zhang sq, zhang h. Org Biomol Chem. 2017 Aug 9;15(31):6622-6631. doi: 10.1039/c7ob01353a. Org Biomol Chem. 2017. PMID: 28752166

8

Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents.

Du K, Ma W, Yang C, Zhou Z, Hu S, Tian Y, Zhang H, Ma Y, Jiang X, Zhu H, Liu H, Chen P, Liu Y. Du K, et al. Among authors: zhang h. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1212-1226. doi: 10.1080/14756366.2022.2065672. J Enzyme Inhib Med Chem. 2022. PMID: 35450499 Free PMC article.

9

Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents.

Sun J, Niu Y, Wang C, Zhang H, Xie B, Xu F, Jin H, Peng Y, Liang L, Xu P. Sun J, et al. Among authors: zhang h. Bioorg Med Chem. 2016 Aug 15;24(16):3472-82. doi: 10.1016/j.bmc.2016.05.055. Epub 2016 May 30. Bioorg Med Chem. 2016. PMID: 27288186

10

Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives.

Bai XG, Yu DK, Wang JX, Zhang H, He HW, Shao RG, Li XM, Wang YC. Bai XG, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6947-51. doi: 10.1016/j.bmcl.2012.08.117. Epub 2012 Sep 8. Bioorg Med Chem Lett. 2012. PMID: 23036956

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