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CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.
Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD. Kramer NJ, et al. Among authors: tsui ck. Nat Genet. 2018 Apr;50(4):603-612. doi: 10.1038/s41588-018-0070-7. Epub 2018 Mar 5. Nat Genet. 2018. PMID: 29507424 Free PMC article.
Finding host targets for HIV therapy.
Tsui CK, Gupta A, Bassik MC. Tsui CK, et al. Nat Genet. 2017 Jan 31;49(2):175-176. doi: 10.1038/ng.3777. Nat Genet. 2017. PMID: 28138150
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.
Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC. Haney MS, et al. Among authors: tsui ck. Nat Genet. 2018 Dec;50(12):1716-1727. doi: 10.1038/s41588-018-0254-1. Epub 2018 Nov 5. Nat Genet. 2018. PMID: 30397336 Free PMC article.
Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.
Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC. Morgens DW, et al. Among authors: tsui ck. Elife. 2019 Nov 1;8:e48434. doi: 10.7554/eLife.48434. Elife. 2019. PMID: 31674906 Free PMC article.
CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells.
Ruetz TJ, Pogson AN, Kashiwagi CM, Gagnon SD, Morton B, Sun ED, Na J, Yeo RW, Leeman DS, Morgens DW, Tsui CK, Li A, Bassik MC, Brunet A. Ruetz TJ, et al. Among authors: tsui ck. Nature. 2024 Oct;634(8036):1150-1159. doi: 10.1038/s41586-024-07972-2. Epub 2024 Oct 2. Nature. 2024. PMID: 39358505 Free PMC article.
Lipid homeostasis is essential for a maximal ER stress response.
Garcia G, Zhang H, Moreno S, Tsui CK, Webster BM, Higuchi-Sanabria R, Dillin A. Garcia G, et al. Among authors: tsui ck. Elife. 2023 Jul 25;12:e83884. doi: 10.7554/eLife.83884. Elife. 2023. PMID: 37489956 Free PMC article.
Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span.
Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, Fan W, Moaddeli D, Tsui CK, Castro Torres T, Alcala A, Moehle EA, Hoang S, Shalem O, Adams PD, Thorwald MA, Higuchi-Sanabria R. Garcia G, et al. Among authors: tsui ck. Aging Cell. 2023 Jan;22(1):e13742. doi: 10.1111/acel.13742. Epub 2022 Nov 20. Aging Cell. 2023. PMID: 36404134 Free PMC article.
131 results